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http://dx.doi.org/10.3746/pnf.2012.17.4.245

Effects of Collagen Tripeptide Supplement on Photoaging and Epidermal Skin Barrier in UVB-exposed Hairless Mice  

Pyun, Hee-Bong (Department of Biomaterials Science and Engineering, College of Life Science and Biotechnology, Yonsei University)
Kim, Minji (Department of Biomaterials Science and Engineering, College of Life Science and Biotechnology, Yonsei University)
Park, Jieun (Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University)
Sakai, Yasuo (Central Research Institute, Jellice Co., Ltd.)
Numata, Noriaki (Central Research Institute, Jellice Co., Ltd.)
Shin, Jin-Yeong (Amorepacific Corporation R&D Center)
Shin, Hyun-Jung (Amorepacific Corporation R&D Center)
Kim, Do-Un (Food R&D Center, Newtree Co., Ltd.)
Hwang, Jae-Kwan (Department of Biomaterials Science and Engineering, College of Life Science and Biotechnology, Yonsei University)
Publication Information
Preventive Nutrition and Food Science / v.17, no.4, 2012 , pp. 245-253 More about this Journal
Abstract
Collagen tripeptide (CTP) is a functional food material with several biological effects such as improving dry skin and wound and bone fracture healing. This study focused on the anti-photoaging effects of CTP on a hairless mouse model. To evaluate the effects of CTP on UVB-induced skin wrinkle formation in vivo, the hairless mice were exposed to UVB radiation with oral administration of CTP for 14 weeks. Compared with the untreated UVB control group, mice treated with CTP showed significantly reduced wrinkle formation, skin thickening, and transepidermal water loss (TEWL). Skin hydration and hydroxyproline were increased in the CTP-treated group. Moreover, oral administration of CTP prevented UVB-induced MMP-3 and -13 activities as well as MMP-2 and -9 expressions. Oral administration of CTP increased skin elasticity and decreased abnormal elastic fiber formation. Erythema was also decreased in the CTP-treated group. Taken together, these results strongly suggest that CTP has potential as an anti-photoaging agent.
Keywords
collagen tripeptide (CTP); photoaging; matrix metalloproteinases (MMPs); transepidermal water loss (TEWL); wrinkle formation;
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