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http://dx.doi.org/10.3746/jfn.2010.15.1.001

Suppressed Fat Accumulation in Rats Fed a Histidine-Enriched Diet  

Endo, Michiko (Department of Bioscience and Food Production Science, Interdisciplinary Graduate School of Science and Technology, Shinshu University)
Kasaoka, Seiichi (Department of Health and Nutrition, Bunkyo University Women's College)
Takizawa, Miki (Department of Health and Nutrition, Bunkyo University Women's College)
Goto, Kiyoko (Department of Health and Nutrition, Bunkyo University Women's College)
Nakajima, Shigeru (Department of Health and Nutrition, Bunkyo University Women's College)
Moon, Soo-Kyung (Department of Food and Nutrition, College of Natural Sciences, Gyeongsang National University)
Kim, In-Soo (Department of Food and Nutrition, College of Natural Sciences, Gyeongsang National University)
Jeong, Bo-Young (Department of Food and Nutrition, College of Natural Sciences, Gyeongsang National University)
Nakamura, Soichiro (Department of Bioscience and Food Production Science, Interdisciplinary Graduate School of Science and Technology, Shinshu University)
Publication Information
Preventive Nutrition and Food Science / v.15, no.1, 2010 , pp. 1-6 More about this Journal
Abstract
The effect on body fat accumulation on male Wistar rats undergoing continuous feeding with a histidine-enriched diet was investigated. Five-week-age rats were assigned to two groups and were fed either the control diet (purified diet AIN-$76^{TM}$) or the histidine-enriched diet containing 3% histidine for 28 days. It was observed that both adipose tissue masses in retroperitoneal and epididymal areas of rats fed histidine-enriched diet significantly decreased (p<0.05) compared to those of control rats, while there was no significant difference in the food efficiency ratio between them. The blood levels of histidine derivatives of 3-methylhistidine and carnosine were significantly (p<0.05) increased in the rats fed a histidine-enriched diet, whereas there were no significant different between the histidine-enriched diet and control groups in the general amino acid distribution. Our results demonstrate that a histidine-enriched diet suppresses body fat accumulation in rats.
Keywords
wistar rat; histidine-enriched diet; adipose tissue mass; fat accumulation; 3-methylhistidine; carnosine;
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