Browse > Article
http://dx.doi.org/10.3746/jfn.2008.13.4.281

Cherry Tomatoes Ameliorate Scopolamine-induced Amnesia in Mice  

Choi, Won-Hee (Functional Food Technology Research Center, Korea Food Research Institute)
Ahn, Ji-Yun (Functional Food Technology Research Center, Korea Food Research Institute)
Kim, Su-Na (Functional Food Technology Research Center, Korea Food Research Institute)
Ha, Tae-Youl (Functional Food Technology Research Center, Korea Food Research Institute)
Publication Information
Preventive Nutrition and Food Science / v.13, no.4, 2008 , pp. 281-285 More about this Journal
Abstract
Cherry tomatoes are rich in antioxidants, which may protect against neurodegeneration and consequent memory loss. This study was conducted to investigate the effect of cherry tomatoes on scopolamine-induced amnesia in mice. Male ICR mice (4 weeks old) were maintained for 4 weeks on a diet containing 10 or 20% tomato powder (TP), and then administered scopolamine (1 mg/kg body weight, i.p.) 45 min before memory testing. Passive avoidance and Morris water maze testing revealed that scopolamine-induced amnesia was significantly reduced in the TP groups compared to the non TP-received (control) group. Accordingly, acetylcholinesterase activities in the serum and brain of TP groups were lower than those in the control group. These findings suggest that cherry tomatoes may be useful for the prevention of neurodegenerative diseases such as amnesia and Alzheimer's disease.
Keywords
acetylcholinesterase; cherry tomato; Morris water maze task; passive avoidance task; scopolamine;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Ellman GL, Courtney KD, Andres VJ, Featherstone RM. 1961. A new and rapid colormetric determination of acetylcholinesterase activity. Biochem Pharmacol 7: 88-95   DOI   ScienceOn
2 Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. 1993. Protein measurement with Folin phenol reagent. J Biol Chem 193: 265-275
3 Fan Y, Hu JF, Li J, Yang Z, Xin XL, Wang J, Ding J, Geng MY. 2005. Effect of acidic oligosaccharide sugar chain on scopolamine-induced memory impairment in rats and its related mechanisms. Neurosci Lett 374: 222-226   DOI   ScienceOn
4 Levy AI. 1996. Muscarinic acetylcholine receptor expression in memory circus; implications for treatment of Alzheimer disease. Proc Natl Acad Sci 93: 13541-13546   DOI
5 Siddiqui MF, Levey AI. 1999. Cholinergic therapies in Alzheimer's disease. Drug Future 24: 417-444   DOI
6 Aust O, Sies H, Atahl W, Polidory MC. 2001. Analysis of lipophilic abtioxidants in human serum and tissues: tocopherols and carotenoids. J Chromatogr 936: 83-93   DOI   ScienceOn
7 Rao AV, Agarwal S. 1999. Role of lycopene as antioxidant carotenoid in the prevention of chronic disease: a review. Nutr Res 19: 305-323   DOI   ScienceOn
8 Lee SY, Son DH, Ha TY, Hong JT. 2005. Protective effect of sesaminol glucosides on memory impairment and ${\beta}$, ${\gamma}$-secretase activity in vivo. Yahhak Hoeji 49: 168-173   과학기술학회마을
9 Jones GMM, Sahakian BJ, Levy R, Warburton DM, Gray JA. 1992. Effects of acute subcutaneous nicotine on attention, information processing and short-term memory in Alzheimer's disease. Psychopharmacology 108: 485-494   DOI
10 Ebert U, Kirch W. 1998. Scopolamine model of dementia: electroencephalogram findings and cognitive performance. Eur J Clin Invest 28: 944-949   DOI   ScienceOn
11 Bhuvaneswari V, Nagini S. 2005. Lycopene: a review of its potential as an anticancer agent. Curr Med Chem Anticancer Agents 5: 627-635   DOI
12 Clinton SK. 2000. Lycopene: chemistry, biology, and implications for human health and disease. Nutr Rev 56: 35-51   DOI   ScienceOn
13 Morris RG. 1984. Development of water maze procedure for studying spatial learning in the rat. J Neurosci Methods 11: 47-60   DOI   ScienceOn
14 Cutler NR, Stramelk JJ. 2001. Review of the next generation of Alzheimer's disease therapeutics; challenges for drug development. Prog Neuropsychopharmacol Biol Psychiatry 25: 27-57   DOI   ScienceOn
15 Ezio G. 1998. Cholinesterase inhibitors for Alzheimer's disease therapy: from tacrines to future applications. Neurochem Int 32: 413-419   DOI   ScienceOn
16 Emilla AM M, Resina LM, F, Danilo WF, Daniela N, Fabiola S, France B, Emil K. 2005. Effects of diet energy level and tomato powder consumption on antioxidant status in rats. Clin Nutr 24: 1038-1046   DOI   ScienceOn
17 Beatty WW, Butters N, Janowsky D. 1986. Memory failure after scopolamine treatment: implications for cholinergic hypothesis of dementia. Behav Neural Biol 45: 196-211   DOI   ScienceOn
18 Levy ML, Cummings JL, Kahn-Rose R. 1999. Neuropsychiatric symptoms and cholinergic therapy for Alzheimer's disease. Gerontol 45: 15-22   DOI   ScienceOn
19 Musial A, Bajda M, Malawska B. 2007. Recent develop ments in cholinesterases inhibitors for Alzheimer's disease treatment. Curr Med Chem 14: 2654-2679   DOI   ScienceOn
20 Kim DH, Kim DY, Kim YC, Jung JW, Lee SJ, Yoon BH, Cheong JH, Kim YS, Kang SS, Ko KH, Ryu JH. 2007. Nodakain, a coumarin compound, ameliorates scopolamine-induced memory disruption in mice. Life Sci 80: 1944-1950   DOI   ScienceOn
21 Eidi M, Zarrindast MR, Eidi A, Oryan S, Parivar K. 2003. Effects of histamine and cholinergic systems on memory retention of passive avoidance learning in rats. Eur J Pharmacol 465: 91-96   DOI   ScienceOn
22 Heber D, Lu QY. 2002. Overview of mechanisma of action of lycopene. Exp Bio Med 227: 920-923   DOI
23 Dunnett SB, Toniolo G, Fine A, Ryan CN, Bjorklund A, Iversen SD. 1985. Transplantation of embryonic ventral forebrain neurons to the nucleus basalis magnocellularis: II. Sensorimotor and learning impairments. Neuroscience 16: 787-797   DOI   ScienceOn
24 Zhong CB, Pan YP, Tong XY, Xu XH, Wang XL. 2005. Delayed rectifier potassium currents and Kv2.1 mRNA increase in hippocampal neurons of scopolamine-induced memory-deficient rats. Neurosci Lett 373: 99-104   DOI   ScienceOn
25 Collerton D. 1986. Cholinergic function and intellectual decline in Alzheimer's disease. Neuroscience 19: 1-28   DOI   ScienceOn
26 Rao AV, Agarwal S. 2000. Role of antioxidant lycopene in cancer and heart disease. J Am Coll Nutr 19: 563-569   DOI
27 Rao AV, Ray MR, Rao LG. 2006. Lycopene. Adv Food Nutr Res 51: 99-164   DOI   ScienceOn
28 George B, Kaur C, Khurdiya DS, Kapoor HC. 2004. Antioxidant in tomato (Lycopene esculentum) as a function of genotype. Food Chem 84: 45-51   DOI   ScienceOn