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http://dx.doi.org/10.3746/jfn.2007.12.1.001

Effects of Colostrum Basic Protein from Colostrum Whey Protein: Increases in Osteoblast Proliferation and Bone Metabolism  

Lee, Jeong-Rai (RexGene Biotech Co.)
Kim, Hyun-Mi (RexGene Biotech Co.)
Choi, Hee-Sun (Food Science Institute, School of Food and Life Science, Inje University)
Hong, Jeong-Hwa (Food Science Institute, School of Food and Life Science, Inje University)
Publication Information
Preventive Nutrition and Food Science / v.12, no.1, 2007 , pp. 1-6 More about this Journal
Abstract
Colostrum basic proteins (CBP) (MW 1$\sim$30 kDa) were isolated from bovine colostrum using a series of ultrafiltration processes and their effects on osteoblast cell proliferation and bone metabolism were investigated in cell line and animal models. Treatments with CBP (1, 10, 100 $\mu$g/mL) dose-dependently increased cell proliferation of osteoblastic MC3T3 cells. Alkaline phosphatase activity, a marker of osteoblastic phenotype, in the cells was also increased after treatments with CBP in a dose-dependent manner. Significant increases in bone density were observed in femur of ovariectomized rats which were fed a diet with 1% and 10% CBP, compared to rats fed a normal diet. These results suggest that CBP may increase bone mass and density and be useful for the prevention of bone-related diseases.
Keywords
colostrum basic protein; osteoblast; bone density; alkaline phosphatase activity;
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