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http://dx.doi.org/10.3746/jfn.2003.8.2.141

Inhibition of Monamine Oxidase by a Flavone and Its Glycoside from Ixeris dentata Nakai  

Chung, Ha-Sook (Department of Food and Nutrition, Duksung Women's University)
Publication Information
Preventive Nutrition and Food Science / v.8, no.2, 2003 , pp. 141-144 More about this Journal
Abstract
Ixeris dentata Nakai (Compositae) is a perennial herb which has been used as a folk medicine for treating diabetes and gastroenteric troubles in Korea. Active compounds were isolated from the aerial parts of Ixeris dentata through the bioassay-guided fractionation and isolation method evaluated for inhibition of monoamine oxidase (MAO) in vitro. The compounds were identified as 5,7,3',4'-tetrahydroxyflavone (1) and 5,7,3',4'- tetrahydroxyflavone 7-glucoside (2), based on physical and spectroscopic characteristics. Compounds 1 and 2 showed a selective inhibition of type B MAO (MAO-B) activity, with IC/sub 50/ values of 15.3 μM and 36.4 μM, respectively, but did not inhibit type A MAO (MAO-A) activity.
Keywords
monoamine oxidase; Ixeris dentata Nakai; flavone; luteolin; cynaroside;
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