Alpha-Lipoic Acid Inhibits Glycogen Synthesis and Modifies Glucose Metabolism and Signaling Pathways in Soleus Muscles from Healthy Rats |
Madar, Zecharia
(The Hebrew University of Jerusalem, Faculty of Agricultural, Food and Environmental Quality Sciences, Institute of Biochemistry, Food Science and Nutrition)
Stark, Aliza H. (The Hebrew University of Jerusalem, Faculty of Agricultural, Food and Environmental Quality Sciences, Institute of Biochemistry, Food Science and Nutrition) Ilan, Erez (The Hebrew University of Jerusalem, Faculty of Agricultural, Food and Environmental Quality Sciences, Institute of Biochemistry, Food Science and Nutrition) Timar, Bracha (The Hebrew University of Jerusalem, Faculty of Agricultural, Food and Environmental Quality Sciences, Institute of Biochemistry, Food Science and Nutrition) Borenshtein, Diana (The Hebrew University of Jerusalem, Faculty of Agricultural, Food and Environmental Quality Sciences, Institute of Biochemistry, Food Science and Nutrition) |
1 | Jacob S, Streeper RS, Fogt DL, Hokama JY, Tritschler HJ, Dietze GJ, Henriksen EJ. 1996. The antioxidant alpha-lipoic acid enhances insulin-stimulated glucose metabolism in insulin-resistant rat skeletal muscle. Diabetes 45: 1024-1029 DOI ScienceOn |
2 | Streeper RS, Henriksen EJ, Jacob S, Hokama JY, Fogt DL, Tritschler HJ. 1997. Differential effects of lipoic acid stereoisomers on glucose metabolism in insulin-resistant skeletal muscle. Am J Physiol 273: E185-191 |
3 | Wallberg-Henriksson H, Zetan N, Henriksson J. 1987. Reversibility of decreased insulin-stimulated glucose transport capacity in diabetic muscle with in vitro incubation. Insulin is not required. J Biol Chem 262: 7665-7671 |
4 | Katz A, Westerblad H. 1995. Insulin-mediated activation of glycogen synthase in isolated skeletal muscle: role of mitochondrial respiration. Biochim Biophys Acta 1244: 229-232 DOI ScienceOn |
5 | Rigden DJ, Jellyman AE, Frayn KN, Coppack SW. 1990. Human adipose tissue glycogen levels and responses to carbohydrate feeding. Eur J Clin Nutr 44: 689-692 |
6 | Espinal J, Dohm GL, Newsholme EA. 1983. Sensitivity to insulin of glycolysis and glycogen synthesis of isolated soleus-muscle strips from sedentary, exercised and exercise- trained rats. Biochem J 212: 453-458 DOI |
7 | Ramrath S, Tritschler HJ, Eckel J. 1999. Stimulation of cardiac glucose transport by thioctic acid and insulin. Horm Metab Res 31: 632-635 DOI ScienceOn |
8 | Khamaisi M, Potashnik R, Tirosh A, Demshchak E, Rudich A, Tritschler H, Wessel K, Bashan N. 1997. Lipoic acid reduces glycemia and increases muscle GLUT4 content in streptozotocin-diabetic rats. Metabolism 46: 763-768 DOI ScienceOn |
9 | Khamaisi M, Rudich A, Potashnik R, Tritschler HJ, Gutman A, Bashan N. 1999. Lipoic acid acutely induces hypoglycemia in fasting nondiabetic and diabetic rats. Metabolism 48: 504-510 DOI ScienceOn |
10 | Hong YS, Jacobia SJ, Packer L, Patel MS. 1999. The inhibitory effects of lipoic compounds on mammalian pyruvate dehydrogenase complex and its catalytic components. Free Radic Biol Med 26: 685-694 DOI ScienceOn |
11 | Tsakiridis T, Ewart HS, Ramlal T, Volchuk A, Klip A, Estrada DE, Tritschler HJ. 1997. Alpha-lipoic acid stimulates glucose transport into muscle and adipose cells in culture: comparison with actions of insulin and dinitrophenol. In Lipoic Acid in Health and Disease. Fuchs J, Packer L, Zimmer G, eds. Marcel Dekker Inc, New York. p 87-98 |
12 | Youn JH, Gulve EA, Holloszy JO. 1991. Calcium stimulates glucose transport in skeletal muscle by a pathway independent of contraction. Am J Physiol 260: C555-561 |
13 | Lawrence JC, Jr, Roach PJ. 1997. New insights into the role and mechanism of glycogen synthase activation by insulin. Diabetes 46: 541-547 DOI ScienceOn |
14 | Markuns JF, Wojtaszewski JF, Goodyear LJ. 1999. Insulin and exercise decrease glycogen synthase kinase-3 activity by different mechanisms in rat skeletal muscle. J Biol Chem 274: 24896-24900 DOI |
15 | Yaworsky K, Somwar R, Ramlal T, Tritschler HJ, Klip A. 2000. Engagement of the insulin-sensitive pathway in the stimulation of glucose transport by alpha-lipoic acid in 3T3- L1 adipocytes. Diabetologia 43: 294-303 DOI ScienceOn |
16 | Konrad T, Vicini P, Kusterer K, Hoflich A, Assadkhani A, Bohles HJ, Sewell A, Tritschler HJ, Cobelli C, Usadel KH. 1999. Alpha-lipoic acid treatment decreases serum lactate and pyruvate concentrations and improves glucose effectiveness in lean and obese patients with type 2 diabetes. Diabetes Care 22: 280-287 DOI ScienceOn |
17 | Rudich A, Tirosh A, Potashnik R, Khamaisi M, Bashan N. 1999. Lipoic acid protects against oxidative stress induced impairment in insulin stimulation of protein kinase B and glucose transport in 3T3-L1 adipocytes. Diabetologia 42: 949-957 DOI ScienceOn |
18 | Konrad D, Somwar R, Sweeney G, Yaworsky K, Hayashi M, Ramlal T, Klip A. 2001 The antihyperglycemic drug alpha-lipoic acid stimulates glucose uptake via both GLUT4 translocation and GLUT4 activation- Potential role of p38 mitogen-activated protein kinase in GLUT4 activation. Diabetes 50: 1464-1471 |
19 | Estrada DE, Ewart HS, Tsakiridis T, Volchuk A, Ramlal T, Tritschler H, Klip A. 1996. Stimulation of glucose uptake by the natural coenzyme alpha-lipoic acid/thioctic acid: participation of elements of the insulin signaling pathway. Diabetes 45: 1798-1804 DOI ScienceOn |
20 | Jacob S, Ruus P, Hermann R, Tritschler HJ, Maerker E, Renn W, Augustin HJ, Dietze GJ, Rett K. 1999. Oral administration of RAC-alpha-lipoic acid modulates insulin sensitivity in patients with type-2 diabetes mellitus: a placebo- controlled pilot trial. Free Radic Biol Med 27: 309-314 DOI ScienceOn |
21 | Jacob S, Henriksen EJ, Schiemann AL, Simon I, Clancy DE, Tritschler HJ, Jung WI, Augustin HJ, Dietze GJ. 1995. Enhancement of glucose disposal in patients with type 2 diabetes by alpha-lipoic acid. Arzneimittelforschung 45: 872- 874 |
22 | Folch J, Lees D, Sloan-Stanley G. 1957 Simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 226: 497-509. |
![]() |