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http://dx.doi.org/10.17495/easdl.2015.12.25.6.999

A Study on Inhibitory Activities on Carbohydrase and Anti-Inflammatory Activities of Hot-Water and Ethanol Extracts from Immature Dried Bitter Melon (Momordica charantia L.)  

Nam, Seung-Woo (Dept. of Food Science and Nutrition, Kyungpook National University)
Kim, Meera (Dept. of Food Science and Nutrition, Kyungpook National University)
Publication Information
Journal of the East Asian Society of Dietary Life / v.25, no.6, 2015 , pp. 999-1006 More about this Journal
Abstract
Bitter melon (Momordica charantia L.) has been used as a medicinal plant due to its biological activity. This study investigated the inhibitory effects on carbohydrase and anti-inflammatory effects of hot-water extract (WEM) and ethanol extract (EEM) from dried bitter melon cultivated in Korea. The inhibitory activities of EEM against ${\alpha}$-amylase and ${\alpha}$-glucosidase were over 70% at 4,000 ppm. The inhibitory activities of EEM were significantly higher than those of WEM at all concentrations. The anti-inflammatory effects were evaluated by measuring nitric oxide (NO) production in LPS-stimulated RAW264.7 cells. EEM did not show cytotoxicity on RAW264.7 cells at the test concentrations. Moreover, the inhibitory effect on NO production in LPS-stimulated RAW264.7 cells was significantly increased by the addition of EEM. These findings suggest that EEM has good inhibitory effect on carbohydrase and anti-inflammatory activity and it has potential as a source of natural functional material.
Keywords
Bitter melon; carbohydrase; anti-inflammatory activity;
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Times Cited By KSCI : 7  (Citation Analysis)
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