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http://dx.doi.org/10.17495/easdl.2015.10.25.5.806

Effect of Hot Water Extract from Curcuma longa L. on Inflammatory Mediators in Prostate Tissue of BPH-Induced Rats  

Lee, Jeong Yoon (Dept. of Food Science and Nutrition, Suwon University)
Kim, Yungjae (Korea INS Pharm Inc.)
Jun, Woojin (Dept. of Food and Nutrition, Chonnam National University)
Lee, Yoo-Hyun (Dept. of Food Science and Nutrition, Suwon University)
Publication Information
Journal of the East Asian Society of Dietary Life / v.25, no.5, 2015 , pp. 806-812 More about this Journal
Abstract
Prostatic inflammation plays a crucial role on benign prostate hyperplasia (BPH) pathogenesis and progression. In this study, BPH was induced by testosterone propinate in castrated rats for 8 weeks. Hot water extract from Curcuma longa L. (CL) was administered orally for 4 weeks along with positive controls, saw Palmetto and finasteride. CL supplementation induced histological changes, reduced expression of TNF-${\alpha}$, IL-6, IL-$1{\beta}$, COX-2, and phospo-p65 in prostate tissue compared with the BPH group. These findings suggest that suppression of pro-inflammatory cytokines could be attributed, at least partly, to the anti-inflammatory action of C. longa, and this action may be helpful to understand the inhibitory effect of Curcuma longa L. in BPH.
Keywords
Curcuma longa L.; benign prostate hyperplasia; pro-inflammatory cytokines; BPH-induced rat;
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1 Nunez C, Cansino JR, Bethencourt F, Perez-Utrilla M, Fraile B, Martinez-Onsurbe P, Olmedilla G, Paniagua R, Royuela M (2008) TNF/IL-1/NIK/NF-${\kappa}B$ transduction pathway: A comparative study in normal and pathological human prostate (benign hyperplasia and carcinoma). Histopathology 53: 166-176.   DOI
2 Park DS, Shim JY (2008) Histologic influence of doxazosin and finasteride in benign prostatic hyperplasia accompanying chronic inflammation. Urol Int 81: 441-446.   DOI
3 Roehrborn CG (2008) Pathology of benign prostatic hyperplasia. Int J Impotence Res 20: S11-S18.
4 Shin IS, Lee MY, Jung DY, Seo CS, Ha HK, Shin HK (2012) Ursolic acid reduces prostate size and dihydrotestosterone level in a rat model of benign prostatic hyperplasia. Food Chem Toxicol 50: 884-888.   DOI
5 Sikka SC (2003) Role of oxidative stress response elements and antioxidants in prostate cancer pathobiology and chemoprevention-A mechanistic approach. Curr Med Chem 10: 2679-2692.   DOI
6 Timms BG, Hofkamp LE (2011) Prostate development and growth in benign prostatic hyperplasia. Differentiation 82: 173-183.   DOI
7 Vendramini-Costa DB, Carvalho JE (2012) Molecular link mechanisms between inflammation and cancer. Curr Pharm Des 18: 3831-3852.   DOI
8 Ahmad M, Suhail N, Mansoor T, Banu N, Ahmad S (2012) Evaluation of oxidative stress and DNA damage in benign prostatic hyperplasia patients and comparison with controls. Indian J Clin Biochem 27: 385-388.   DOI
9 Aryal M, Pandeya A, Bas BK, Lamsal M, Majhi S, Pandit R, Agrawal CS, Gautam N, Baral N (2007) Oxidative stress in patients with benign prostate hyperplasia. J Nepal Med Assoc 46: 103-106.
10 Atawia RT, Mosli HH, Tadros MG, Khalifa AE, Mosli HA, Abdel-Naim AB (2014) Modulatory effect of silymarin on inflammatory mediators in experimentally induced benign prostatic hyperplasia: Emphasis on PTEN, HIF-$1{\alpha}$, and NF-${\kappa}B$. Naunyn Schmiedebergs Arch Pharmacol 387: 1131-1140.   DOI
11 Bernichtein S, Pigat N, Camparo P, Latil A, Viltard M, Friedlander G, Goffin V (2015) Anti-inflammatory properties of lipidosterolic extract of Serenoa repens ($Permixon^{(R)}$) in a mouse model of prostate hyperplasia. Prostate 75: 706-22.   DOI
12 Berry SJ, Coffey DS, Walsh PC, Ewing LL (1984) The development of human benign prostatic hyperplasia with age. J Urol 132: 474-479.   DOI
13 Bostanci Y, Kazzazi A, Momtahen S, Laze J, Djavan B (2013) Correlation between benign prostatic hyperplasia and inflammation. Curr Opin Urol 23: 5-10.   DOI
14 Elberry AA, Mufti ST, Al-Maghrabi JA, Abdel-Sattar EA, Ashour OM, Ghareib SA, Mosli HA (2011) Anti-inflammatory and antiproliferative activities of date palm pollen (Phoenix dactylifera) on experimentally-induced atypical prostatic hyperplasia in rats. J Inflamm (Lond) 8: 40-53.   DOI
15 Elberry AA, Mufti S, Al-Maghrabi J, Abdel Sattar E, Ghareib SA, Mosli HA, Ghareib SA (2014) Immunomodulatory effect of red onion (Allium cepa Linn) scale extract on experimentally induced atypical prostatic hyperplasia in Wistar rats. Mediators Inflamm 640746.
16 Gandaglia G, Briganti A, Gontero P, Mondaini N, Novara G, Salonia A, Sciarra A, Montorsi F (2013) The role of chronic prostatic inflammation in the pathogenesis and progression of benign prostatic hyperplasia (BPH). BJU Int 112: 432-441.   DOI
17 Kramer G, Marberger M (2006) Could inflammation be a key component in the progression of benign prostatic hyperplasia? Curr Opin Urol 16: 25-29.
18 Ho JN, Jang JY, Yoon HG, Kim Y, Kim S, Jun W, Lee J (2012) Anti-obesity effect of a standardised ethanol extract from Curcuma longa L. fermented with Aspergillus oryzae in ob/ob mice and primary mouse adipocytes. J Sci Food Agric 92: 1833-1840.   DOI
19 Illuri R, Bethapudi B, Anandakumar S, Murugan S, Joseph JA, Mundkinajeddu D, Agarwal A, Chandrasekaran CV (2015) Anti-Inflammatory activity of polysaccharide fraction of Curcuma longa extract (NR-INF-02). Antiinflamm Antiallergy Agents Med Chem 14: 53-62.   DOI
20 Kim J, Jeong SW, Quan H, Jeong CW, Choi JI, Bae HB (2015) Effect of curcumin (Curcuma longa extract) on LPSinduced acute lung injury is mediated by the activation of AMPK. J Anesth Sep 3. [Epub ahead of print].
21 Latil A, Pétrissans MT, Rouquet J, Robert G, de la Taille A (2015) Effects of hexanic extract of serenoa repens ($permixon^{(R)}$ 160 mg) on inflammation biomarkers in the treatment of lower urinary tract symptoms related to benign prostatic hyperplasia. Prostate 75:1857-1867.   DOI
22 McCann MJ, Johnston S, Reilly K, Men X, Burgess EJ, Perry NB, Roy NC (2014) The effect of turmeric (Curcuma longa) extract on the functionality of the solute carrier protein 22 A4 (SLC22A4) and interleukin-10 (IL-10) variants associated with inflammatory bowel disease. Nutrients 6: 4178-4190.   DOI
23 Minutoli L, Bitto A, Squadrito F, Marini H, Irrera N, Morgia G, Passantino A, Altavilla D (2013) Serenoa repens, lycopene and selenium: A triple therapeutic approach to manage benign prostatic hyperplasia. Curr Med Chem 20: 1306-1312.   DOI