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Effect of $Panax$ $ginseng$ C.A. Meyer Extract (Ginseol K-b1) on UVB-induced Skin Damage in Hairless Mice  

Chang, Jeong-Hwa (Foods R&D, CJ CheilJedang Corporation)
Hwang, Se-Hee (Foods R&D, CJ CheilJedang Corporation)
Lee, Eun-Ju (Foods R&D, CJ CheilJedang Corporation)
Ohto, Nobuaki (R&D Division, Maruzen Pharmaceutical Co. LTD.)
Lee, Jin-Hee (Dept. of Food Science and Biotechnology, CHA University)
Publication Information
Journal of the East Asian Society of Dietary Life / v.22, no.2, 2012 , pp. 224-230 More about this Journal
Abstract
To investigate the effect of Panax ginseng C.A. Meyer extract (Ginseol K-b1), on skin functionality, we evaluated skin appearance and properties, such as wrinkle formation, skin moisture content, and skin elasticity in the skin of hairless mice damaged by UV irradiation. In addition, the effect of Ginseol K-b1 on collagen synthesis in human dermal fibroblasts was investigated. Female hairless mice were orally administered Ginseol K-b1 for 10 weeks with UV irradiation. Wrinkle formation in the Ginseol K-b1-treated group was significantly suppressed compared to the UV-irradiated group. Skin properties, including skin moisture content and elasticity, of the Ginseol K-b1-treated group were better than those of the control group. In the human fibroblast cells, Ginseol K-b1 treatment enhanced cell proliferation and significantly stimulated collagen synthesis. These results suggest that Ginseol K-b1 is a potent ingredient with anti-aging effects.
Keywords
UV-induced skin damage; Panax ginseng extract; anti-wrinkle; anti-photoaging;
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