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http://dx.doi.org/10.5187/JAST.2007.49.6.711

Investigation of Coat Color Candidate Genes in Korean Cattle(Hanwoo)  

Do, K.T. (Department of Animal Science, Chungbuk National University)
Shin, H.Y. (Department of Animal Science, Chungbuk National University)
Lee, J.H. (Department of Animal Science, Chungbuk National University)
Kim, N.S. (Department of Animal Science, Chungbuk National University)
Park, E.W. (National Livestock Research Institute, RDA)
Yoon, D.H. (National Livestock Research Institute, RDA)
Kim, K.S. (Department of Animal Science, Chungbuk National University)
Publication Information
Journal of Animal Science and Technology / v.49, no.6, 2007 , pp. 711-718 More about this Journal
Abstract
Most cattle breeds have a coat color pattern that is characteristic for the breed. Korean cattle(Hanwoo) has a coat color ranging from yellowish brown to dark brown including a red coat color. Variation in the Hanwoo coat color is likely to be the effects of modified genes segregating within the Hanwoo breed. MC1R encoded by the Extension(E) locus was almost fixed with recessive red e allele in the Hanwoo, but other gene(s) might be affecting the variation of the Hanwoo coat color into yellowish to red brown. We have analyzed a segregation of coat color in the F2 families generated from two Hanwoo bulls(yellowish brown) mated to six F1 dams(black) derived from Hanwoo and Holstein crosses. Segregation of coat color in the offspring found a ratio of 1(yellowish brown) : 1(black) and this ratio indicates that a single gene may play a major role for the Hanwoo coat color. We further investigated SNPs in MC1R, ASIP and TYRP1 loci to determine genetic cause of the Hanwoo coat color. Several polymorphisms within ASIP intron 2 and TYRP1 exons were found but not conserved within the Hanwoo population. However, the segregation of the MC1R e allele was completely associated with the Hanwoo coat color. Based on this information, it is clear that the MC1R e allele is mainly responsible for the yellowish red Hanwoo coat color. Further study is warrant to identify possible genetic interaction between MC1R e allele and other coat color related gene(s) for the variation of Hanwoo coat color from yellowish brown to dark brown. (Key words : Hanwoo, Coat color, SNP, MC1R, ASIP, TYRP1)
Keywords
Hanwoo; Coat color; SNP; MCIR; ASIP; TYRP1;
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  • Reference
1 Jackson, I. J. 1997. Homologous pigmentation mutations in human, mouse and other model organisms. Human Molecular Genetics. Vol 6, No. 10
2 Klungland, H., Vage, D. I., Gomez-Raya, L., Adalsteinsson, S. and Lien. S. 1995. The role of melanocyte-stimulating hormone (MSH) receptor in bovine coat colour determination. Mamm. Genome 6, 636-639   DOI
3 Vage, D. I., Klungland, H., Lu, D. and Cone, R. D. 1999. Molecular and pharmacological characterization of dominant black coat color in sheep. Mamm. Genome 10:39   DOI
4 이성수, 양영훈, 강승률, 오운용, 양보석, 고서봉, 오성종, 김규일. 2000. 한우, 제주재래흑우, 흑모 화우와 갈모화우에서의 MSH receptor(MCIR) 유전자의 유전자형 빛 빈도 비교. 한국동물자원과학회지. 42,253-260
5 Barsh, G. S. 1996. The genetics of pigmentation: from fancy genes to complex traits. Trends Genet 12, 299-305   DOI   ScienceOn
6 Berryere, T. G., Schmutz, S. M., Schimpf, R. J., Cowan, C. M. and Potter, J. 2003. TYRPI is associated with dun coat colour in Dexter cattle or how now brown cow. Anim. Genet. 34, 169-175   DOI   ScienceOn
7 Cone, R. D., Lu, D., Koppula, S., Vage, D. I., Klungland, H., Boston, B., Chen, W., Orth, D. N., Pouton, C. and Kesterson, R. A. 1996. The Melanocortin Receptors: Agonists, Antagonists, and the Hormonal Control of Pigmentation. Recent Progress in Hormone Research. Vol. 51
8 Rieder, S., Stricker, C. H., Joerg, H., Dummer, R. and Stranzinger, G. 2000. A comparative genetic approach for the investigation of aging grey horse melanoma. J Anim Breed Genet 117, 73-82   DOI   ScienceOn
9 Klungland, H., Olsen, H. G., Hassanane, M. S., Mahrous, K. and Vage, D. I. 2000. Coat color gene in diversity studies. J. Anim. Breed. Genet. 117,217-224   DOI   ScienceOn
10 Ortonnc, J. P. and Prota, G. 1993. Hair melanins and hair color: ultrastructural and biochemical aspects. J Invest Dermatol 101:82S-89S   DOI   ScienceOn
11 Rieder, S., Taourit, S., Mariat, D., Langlois, B. and Guerin, G. 2001. Mutations in the agouti (ASIP), the extension (MC1R), and the brown (TYRP1) loci and their association to coat color phenotypes in horses (Equus caballus). Mamm Genome 12:450-455   DOI
12 Sasazaki et al. 2005. Allele frequencies of the extention locus encoding the melanocortin-1 receptor in Japanese and Korean cattle. Animal Science Journal. 76. 129-132   DOI   ScienceOn