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http://dx.doi.org/10.5720/kjcn.2012.17.6.714

Nutrient Intake, the Concentrations of Leptin, Adiponectin, Cotisol & Insulin by the Body Fat Content of Women  

Lee, Soon Yei (Department of Health and Welfare, Graduate School of Lifetime Welfare Sungshin Women's University)
Bae, Hyun Sook (Department of Health and Welfare, Graduate School of Lifetime Welfare Sungshin Women's University)
Publication Information
Korean Journal of Community Nutrition / v.17, no.6, 2012 , pp. 714-723 More about this Journal
Abstract
The aim of this study was to compare nutrient intakes, serum hormones (leptin, adiponectin, insulin), salivary cortisol and ${\alpha}$-amylase of middle-aged women by the percentage of body fat (% fat). Subjects were assigned to 3 groups by body fat (%) group I (27.5%), group II (32.5%), group III (37.7%). WHR of group II (0.97) was significantly higher than of group I, III (0.95) (p < 0.05). Nutrient intakes were not different among 3 groups. Serum leptin levels of group III ($16.53{\mu}g/ml$) were higher than in group I ($10.07{\mu}g/ml$), group II ($12.24{\mu}g/ml$) (p < 0.05). Salivary cortisol levels of group II ($0.39{\mu}g/dl$) were higher than in group I ($0.17{\mu}g/dl$) and group III ($0.15{\mu}g/dl$) (p < 0.05). Adiponectin concentrations were negatively correlated with TAS (r = -0.29) and positively correlated with HDL cholesterol (r = 0.27). Insulin levels were negatively correlated with total cholesterol (r = -0.33), Zn intake (r = -0.31) and positively correlated with WHR (r = 0.31). The overall anthropometric indices showed positive relations with leptin levels. Salivary cortisol levels were positively corelated with WHR (r = 0.28), total cholesterol (r = 0.31), MDA (r = 0.29) and intakes of SFA (r = 0.35) and MUFA (r = 0.3). Salivary amylase levels were positively correlated with overall nutrient intakes (energy, CHO, fat, cholesterol. Fe, SFA, MUFA, Zn, Na, vitamin $B_2$, r = 0.24-0.5) and was negatively correlated with HDL cholesterol (r = -0.34). These results suggested that 1) WHR would be a helpful index in the assessment of metabolic risk diseases. 2) Understanding of individual stress exposure should be considered in developing strategies for prevention and treatment of obesity.
Keywords
body fat; leptin; cortisol; adiponectin;
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1 Gavrila A, Chan JL, Yiannakouris N, Kontogianni M, Miller LC, Orlova C, Mantzoros CS (2003): Serum adiponectin levels are inversely associated with overall and central fat distribution but are not directly regulated by acute fasting or leptin administration in humans: cross-sectional and interventional studies. J Clin Endocrinol Metab 88(10): 4823-4831
2 Groesz LM, McCoy S. Carl J, Saslow L, Stewart J, Adler N, Laraia B, Epel E (2012): What is eating you? Stress and the drive to eat. Appetite 58(2): 717-721
3 James PT, Leach R, Kalamara E, Shayeghi M (2001): The worldwide obesity epidemic. Obes Res 9(4): 228-233
4 Kadowaki T, Yamauchi T, Kubota N, Hara K, Ueki K, Tobe K (2006): Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J Clin Invest 116(7): 1784-1792
5 Kang SJ, Shin YA, Kim KJ (2008): The differences of ghrelin, adiponectin, and aerobic capacity by menopause and obesity and its inter-correlation with body composition indexes. Korean J Sport Sci 19(2): 51-59
6 Kim SJ, Park KG, Kim HK, Kim MK, Lee SW, Hwang JS, Han SW, Hur SH, Lee IK (2004): Serum adiponectin concentration according to visceral fat amount and its relationship of metabolic risk factors in premenopausal obese women. Korean J Med 66(3): 259-266
7 Lee HJ, Lee DH, Kim KO, Kim YJ, Lee HY (2009): Analysis of serum antioxidant materials concentration and their relation with blood lipids and anthropometric indices in middle-aged adult in Korea. Korean J Nutr 42(5): 464-473
8 Lee MY, Kim JH (2010): Association of serum lipids and dietary intakes with serum adiponectin level in overweight and obese Korean women. Korean J Community Nutr 15(1): 27-35   과학기술학회마을
9 Lee MY, Kim JH (2011): Comparison of serum insulin, leptin, adiponectin and high sensitivity c-reactive protein levels according to body mass index and their associations in adult women. Korean J Community Nutr 16(1): 126-135
10 Lee SE, Moon JH, Ahn JH, Oh YS, Shinn SH (2007): The association between plasma adiponectin and the components of metabolic syndrome in adults with abdominal obesity. Korean J Obes 16(4): 147-153
11 Lee SW, Kim MR, You YO (2009): Recent clinical review : Adipokines, the obesity and metabolic complications in the postmenopausal women. Korean J Obstetrics Gynecol 52(12): 1204-1211
12 Melissas J, Malliaraki N, Papadakis JA, Taflampas P, Kampa M, Castanas E (2006): Plasma antioxidant capacity in morbidly obese patients before and after weight loss. Obes Surg 16(3): 314-320
13 Mnzberg H, Myers MG Jr (2005): Molecular and anatomical determinants of central leptin resistance. Nat Neurosci 8(5): 566- 570
14 Bruun JM, Lihn AS, Verdich C, Pedersen SB, Toubro S, Astrup A, Richelsen B (2003): Regulation of adiponectin by adipose tissuederived cytokines: in vivo and in vitro investigations in humans. Am J Physiol Endocrinol Metab 285(3): 527-533
15 Canas JA, Damaso L, Altomare A, Killen K, Hossain J, Balagopal PB (2012): Insulin resistance and adiposity in relation to serum $\beta$-carotene levels. J Pediatr 161(1): 58-64
16 Beltowski J (2012): Leptin and the regulation of endothelial function in physiological and pathological conditions. Clin Exp Pharmacol Physiol 39(2): 168-178
17 Dockray S, Susman EJ, Dorn LD (2009): Depression, cortisol reactivity, and obesity in childhood and adolescence. J Adolesc Health 45(4): 344-350
18 Bosy-Westphal A, Brabant G, Haas V, Onur S, Paul T, Nutzinger D, Klein H, Hauer M, Müller MJ (2005): Determinants of plasma adiponectin levels in patients with anorexia nervosa examined before and after weight gain. Eur J Nutr 44(6): 355-359
19 Chang HS (2010): Nutrient intakes and blood lipids according to obesity degree by body fat percentage among middle-aged women in gunsan city. Korean J Community Nutr 15(1): 15-26
20 Daimon M, Oizumi T, Saitoh T, Kameda W, Hitra A, Yamaguchi H, Ohnuma H, Igarashi M, Tominaga M, Kato T (2003): Decreased serum levels of adiponectin are a risk factor for the progression to type 2 diabetes in the japanes population. Diabetes Care 26(7): 2015-2020
21 Duclos M, Gatta B, Corcuff JB, Rashedi M, Pehourcq F, Roger P (2001): Fat distribution in obese women is associated with subtle alterations of the hypothalamic-pituitary-adrenal axis activity and sensitivity to glucocorticoids. Clin Endocrinol 55(4): 447-454
22 Duclos M, Marquez Pereire P, Barat P, Gatta B, Roger P (2005): Increased cortisol bioavailability, abdominal obesity, and the metabolic syndrome in obese women. Obes Res 13(7): 1157-1166
23 Fernandez-Sanchez A, Madrigal-Santillan E, Bautista M, Esquivel- Soto J, Morales-González A, Esquivel-Chirino C, Durante- Montiel I, Sánchez-Rivera G, Valadez-Vega C, Morales-González JA (2011): Inflammation, oxidative stress, and obesity. Int J Mol Sci 12(5): 3117-3132
24 Fried SK, Ricci MR, Russell CD, Lafferrere B (2000) : Regulation of leptin production in humans. J Nutr 130(12): 3127-3131
25 Oltmanns KM, Dodt B, Schultes B, Raspe HH, Schweiger U, Born J, Fehm HL, Peters A (2006): Cortisol correlates with metabolic disturbances in a population study of type 2 diabetic patients. Eur J Endocrinol 154(2): 325-331
26 Garcia-Prieto MD, Tebar FJ, Nicolas F, Larque E, Zamora S, Garaulet M (2007): Cortisol secretary pattern and glucocorticoid feedback sensitivity in women from a mediterranean area: relationship with anthropometric characteristics, dietary intake and plasma fatty acid profile. Clin Endocrinol 66(2): 185-191
27 Fukui T, Yamauchi K, Maruyama M, Yasuda T, Kohno M, Abe Y (2011): Significance of measuring oxidative stress in lifestylerelated diseases from the viewpoint of correlation between d- ROMs and BAP in Japanese subjects. Hypertens Res 34(9): 1041-1045
28 Mohn A, Catino M, Capanna R, Giannini C, Marcovecchio M, Chiarelli F (2005): Increased oxidative stress in prepubertal severely obese children: effect of a dietary restriction-weight loss program. J Clin Endorinol Metab 90(5): 2653-2658
29 Neil AS, B. Rhett R, Paul LB, Brian S, Rodney GB (2011): A review of weight control strategies and their effects on the regulation of hormonal balance. J Nutr Metab 2011: 15
30 Nida Alia, Jens CP (2012): The salivary alpha amylase over cortisol ratio as a marker to assess dysregulations of the stress systems. Physiol Behav 106(1): 65-72
31 Ouchi N, Kihara S, Arita Y, Maeda K, Duriyama H, Okamoto Y, Hotta K, Nishida M, Takahashi M, Nakamura T, Yamashita S, Funahashi T, Matsuzawa Y (1999): Novel molecules: adipocytederived plasma protein adiponectin. Circulation 100(25): 2473- 2476
32 Rolland YM, Perry HM 3rd, Patrick P, Banks WA, Morley JE (2006): Leptin and adiponectin levels in middle-aged postmenopausal women: associations with lifestyle habits, hormones, and inflammatory markers--a cross-sectional study. Metabolism 55(12): 1630-1636
33 Ozata M, Mergen M, Oktenli C, Aydin A, Sanisoglu SY, Bolu E, Yilmax MI, Sayal A, Isimer A, Ozdemir IC (2002): Increased oxidative stress and hypozincemia in male obesity. Clinical Biochemistry 35(8): 627-631
34 Park SB, Blumenthal JA, Lee SY, Georgiades A (2011): Association of cortisol and the metabolic syndrome in Korean men and women. J Korean Med Sci 26(7): 914-918
35 Reaven GM (1988): Role of insulin resistance in human disease. Diabetes 37(12): 1595-1607
36 Rosmond R, Björntorp P (1998): Endocrine and metabolic aberrations in men with abdominal obesity in relation to anxiodepressive infirmity. Metabolism 47(10): 1187-1193
37 Roubenoff R (2004): Sarcopenic obesity: The confluence of two epidemics. Obes Res 12(6): 887-888
38 Srdic B, Stokic E, Polzovic A, Babovic S (2005): Abdominal adipose tissue-significance and methods of defection. Med Pregl 58: 258- 264
39 Steptoe A, Kunz-Ebrecht SR, Brydon L, Wardle J (2004): Central adiposity and cortisol responses to waking in middle-aged men and women. Int J Obes Relat Metab Disord 28(9): 1168-1173
40 Sung CJ, Kim EY (2003): A study of nutritional status and antioxidant capacity according to obesity index in postmenopausal women. J Korean Soc Study Obes 12(3): 193-202