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http://dx.doi.org/10.5851/kosfa.2020.e78

Bioconversion Products of Whey by Lactic Acid Bacteria Exert Anti-Adipogenic Effect  

Lee, Ji Soo (Department of Food Science and Biotechnology, College of Life Science and Biotechnology, Dongguk University)
Hyun, In Kyung (Department of Food Science and Biotechnology, College of Life Science and Biotechnology, Dongguk University)
Yoon, Ji-Won (Department of Food Science and Biotechnology, College of Life Science and Biotechnology, Dongguk University)
Seo, Hye-Jin (Department of Food Science and Biotechnology, College of Life Science and Biotechnology, Dongguk University)
Kang, Seok-Seong (Department of Food Science and Biotechnology, College of Life Science and Biotechnology, Dongguk University)
Publication Information
Food Science of Animal Resources / v.41, no.1, 2021 , pp. 145-152 More about this Journal
Abstract
Microbial bioconversion using lactic acid bacteria (LAB) provides several human health benefits. Although whey and whey-derived bioactive compounds can contribute to an improvement in human health, the potential anti-obesity effect of whey bioconversion by LAB has not been well studied. This study aimed to investigate whether bioconversion of whey by Pediococcus pentosaceus KI31 and Lactobacillus sakei KI36 (KI31-W and KI36-W, respectively) inhibits 3T3-L1 preadipocyte differentiation. Both KI31-W and KI36-W reduced intracellular lipid accumulation significantly, without decreasing 3T3-L1 preadipocyte proliferation. In addition, obesity-related transcription factor (peroxisome proliferator-activated receptor γ) and genes (adipocyte fatty acid-binding protein and lipoprotein lipase) were down-regulated significantly in 3T3-L1 cells in the presence of KI31-W and KI36-W. Collectively, these results suggest that bioconversion of whey by LAB exhibits anti-adipogenic activity and may be applied as a therapeutic agent for obesity.
Keywords
bioconversion; whey; lactic acid bacteria; obesity; 3T3-L1 preadipocyte;
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