Browse > Article
http://dx.doi.org/10.5851/kosfa.2013.33.2.276

Effect of Garcinia cambogia Extract-containing Dip-sauce for Meat on Lipid Accumulation and Body Weight Reduction in Rats Fed High-fat Diet  

Kang, Eun Sil (Department of Animal Biotechnology, Konkuk University)
Hwang, Jung Seok (Department of Animal Biotechnology, Konkuk University)
Kim, Min-Hwa (Mong-Go Foods Co., Ltd.)
Kim, Hye Jung (Department of Pharmacology, Gyeongsang National University School of Medicine)
Lee, Chang-Kwon (Mong-Go Foods Co., Ltd.)
Seo, Han Geuk (Department of Animal Biotechnology, Konkuk University)
Publication Information
Food Science of Animal Resources / v.33, no.2, 2013 , pp. 276-280 More about this Journal
Abstract
Obesity, the leading metabolic disease, is a prevalent health problem in industrialized countries and is closely associated with coronary heart disease, hypertension, diabetes, and even cancer. In this study, we investigated the effects of dip-sauce for meat containing Garcinia cambogia extract (GC) on the lipid accumulation and body weight reduction in rats fed high-fat diet for three months. Eighteen Sprague Dawley male rats of five-week-old were randomly assigned to one of three groups; normal chew diet (NCD) group, high-fat diet plus GC-noncontaining dip-sauce (HFD) group, and HFD plus GC-containing dip-sauce (HFD+GC) group. Co-administration of GC-containing dip-sauce (5 g/kg body weight/day) with HFD significantly attenuated cumulative body weight gain, compared with NCD or HFD groups. Both epididymal and perirenal fat pad weights in the HFD plus GC group were significantly lower than those of HFD or NCD groups. Administration of GC-containing dip-sauce also resulted in significant reduction in the serum levels of total cholesterol, total lipid, and triglyceride, compared with NCD or HFD groups. Thus, GC-containing dip-sauce confers beneficial effects to pathological states associated with metabolic disorder via its anti-obesity and lipid lowering properties.
Keywords
anti-obesity; Garcinia cambogia; lipid accumulation; high-fat diet;
Citations & Related Records
Times Cited By KSCI : 4  (Citation Analysis)
연도 인용수 순위
1 Korea Food and Drug Administration (KFDA). (2010) Health Functional Food Code. Available from http://hfoodi.kfda.go.kr/data/pds_view.jsp?sfield=&skey=null&pageStr=&intIdx= 368&cateIdx=69&categoryCode=18 Accessed Oct. 19, 2010.
2 Korea Health Industry Development Institute (KHIDI). (2012) KHIDI Brief Vol. 40. Available from http://khiss.go.kr/board/bbs_read.jsp?tname=MINBOARD358&bbsid=B304&bbs_seq=273&jkey=BBS_TITLE&jword=%B1%E2%B4%C9%BC%BA&pg=1&htxt_code=1261590435221103952151011 07611485&wj_vcs=. Accessed Sep. 17, 2012.
3 Korea Restaurant Industry (KRI). (2011) Trend of Food Restaurant Industry. No. 704. Available from http://www.foodbank.co.kr/news/view.php?cat_name=%BB%EA%BE%F7%B5%BF%C7%E2&secIndex=29287&page=7§ion=001003&back =I&cat_sel=. Accessed Aug. 12, 2011.
4 Lee, J. J., Shin, H. D., Lee, Y. M., Kim, A. R., and Lee, M. Y. (2009) Effects of broccoli sprouts on cholesterol-lowering and anti-obesity effects in rats fed high fat diet. J. Korean Soc. Food Sci. Nutr. 38, 309-318.   과학기술학회마을   DOI   ScienceOn
5 Marquez, F., Babio, N., Bullo, M., and Salas-Salvado, J. (2012) Evaluation of the safety and efficacy of hydroxycitric acid or Garcinia cambogia extracts in humans. Crit. Rev. Food Sci. Nutr. 52, 585-594.   DOI   ScienceOn
6 Ministry of Health and Welfare (2010) Korea Health Statistics 2010: Korea National Health and Nutrition Examination Survey (KNHANES V-1). Available from http://www. bokjiro.go.kr/data/statueView.do?board_sid=297&data_sid= 5771475. Accessed May. 2, 2012.
7 Park, H. J., Lee, E. J., Kim, J., Kim J. Y., Kwan, O., and Kim, M. K. (2009) Effect of leucine intake on body weight reduction in rats fed high fat diet. Korean J. Nutr. 42, 714-722.   과학기술학회마을   DOI   ScienceOn
8 Park, J. Y. and Kim M. K. (2005) Effects of feeding Garcinia cambogia extract (HCA) and/or L-carnitine and exercise on body weight in rats. Korean J. Nutr. 38, 637-648.
9 Soni, M. G., Burdock, G. A., Preuss, H. G., Stohs, S. J., Ohia, S. E., and Bagchi, D. (2004) Safety assessment of (-)-hydroxycitric acid and Super CitriMax‚, a novel calcium/potassium salt. Food Chem. Toxicol. 42, 1513-1529.   DOI   ScienceOn
10 Vander, A., Shennan, J., and Luciano, D. (2001) Human Physiology: The mechanism of body function. 8th ed, McGraw- Hill, NY, pp.572-573.
11 World Health Organization (2006) Obesity and overweight. Fact sheet No. 311. Available from: http://www.mclveganway. org.uk/Publications/WHO_Obesity_and_overweight.pdf. Accessed Sep. 2006.
12 World Health Organization (2012) Obesity and overweight. Fact sheet No. 311. Available from: http://www.who.int/mediacentre/ factsheets/fs311/en/index. html. Accessed May. 2012.
13 Gatta, B., Zuberbuehler, C., Arnold, M., Aubert, R., Langhans, W., and Chapelot, D. (2009) Acute effects of pharmacological modifications of fatty acid metabolism on human satiety. Br. J. Nutr. 101, 867-1877.
14 Jena, B. S., Jayaprakasha, G. K., Singh, R. P., and Sakariah, K. K. (2002) Chemistry and biochemistry of (-)-hydroxycitric acid from garcinia. J. Agric. Food Chem. 50, 10-22.   DOI   ScienceOn
15 Kim, S. M., Seo, K. I., Park K. W., Jeong, Y. K., Cho, Y. S., Kim, M. J., Kim, E., and Lee M. K. (2009) Effects of crude saponins from soybean cake on body weight and glucose tolerance in high-fat induced obese mice. J. Korean Soc. Food Sci. Nutr. 38, 39-46.   DOI   ScienceOn
16 Kim, Y. H., Yoo, J. Y., Lee, E. G., Kim, K. B., Jo, D. H., and Hwang, J. Y. (2004) Effects of a dietary supplement consisting of Phaseolus vulgaris and Garcinia cambogia (HCA) on the lipid level and body weight. J. Korean Soc. Food Sci. Nutr. 33, 518-522.   과학기술학회마을   DOI   ScienceOn
17 Sallis, J. F., Floyd, M. F., Rodríguez, D. A., and Saelens, B. E. (2012) Role of built environments in physical activity, obesity, and cardiovascular disease. Circulation 125, 729-737.   DOI
18 Kim, Y. J., Jun, H.-S., Park, I. S., Kim, M., Lee, J., Lee, K., and Park, T. (2005) Effect of treadmill exercise training and dietary intake of Garcinia cambogia extract. Soypeptide and L-carnitine mixyure on body weight reduction in rats fed high-fat diet. Korean Nutr. Soc. 38, 626-636.
19 Rícný, J. and Tucek, S. (1982) Acetyl coenzyme A and acetylcholine in slices of rat caudate nuc1eie incubated with (-)-hydroxycitrate, citrate and EGTA. J. Neurochem. 39, 668-673.   DOI
20 Saito, M., Ueno, M., Ogino, S., Kubo, K., Nagata, J., and Takeuchi, M. (2005) High dose of Garcinia cambogia is effective in suppressing fat accumulation in developing male Zucker obsess rats, but highly toxic to the testis. Food Chem. Toxicol. 43, 411-419.   DOI   ScienceOn