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http://dx.doi.org/10.5851/kosfa.2012.32.2.234

Effect of Pig Skin Gelatin Hydrolysates on the Bone Mineral Density of Ovariectomized Rats  

Park, Jeong-Eun (National Institute of Animal Science, RDA)
Ham, Jun-Sang (National Institute of Animal Science, RDA)
Kim, Hey-Kyung (Department of Food and Biotechnology, Hanseo University)
Lee, Chi-Ho (Department of Food Science Biotechnology of Animal Resources, Konkuk University)
Kim, Dong-Wook (National Institute of Animal Science, RDA)
Seol, Kuk-Hwan (National Institute of Animal Science, RDA)
Oh, Mi-Hwa (National Institute of Animal Science, RDA)
Kim, Dong-Hun (National Institute of Animal Science, RDA)
Jang, Ae-Ra (Department of Animal Products and Food Science, Kangwon National University)
Publication Information
Food Science of Animal Resources / v.32, no.2, 2012 , pp. 234-240 More about this Journal
Abstract
This study was conducted to examine the effects of low molecular weight gelatin hydrolysates (GH, less than 3kDa), extracted from pig skin collagen on the bone metabolism of ovariectomized (OVX) rats. The rats in the experimental groups were randomly segregated into six different treatment groups such as 1) NC, the normal rat fed AIN 93 diet (basal diet) only; 2) OC, the OVX rat fed the basal diet only; 3) GH 0.1, the OVX rat fed the basal diet with 0.1% GH; 4) GH 0.8, the OVX rat fed the basal diet with 0.8% GH; 5) G 0.1, the OVX rat fed the basal diet with 0.1% gelatin; 6) G 0.8, the OVX rat fed the basal diet with 0.8% gelatin. Body weight gain in the GH 0.1, GH 0.8, and G 0.8 was significantly higher than those in the NC and OC. Feed intake of the GH 0.1 and GH 0.8 was higher than that of the NC and OC, while no significant difference was found in feed efficiency ratio (FER). BMD of the GH 0.8 was higher than that of the OC. However, gelatin hydrolysates and gelatin resulted in higher BMC level compare to the OC. Serum HDL-cholesterol of rat fed GH and gelatin was higher than that of OC (p<0.05). LDL-C of the GH 0.1 and the GH 0.8 tended to be less than that of OC. Serum alkaline phosphatase (ALP) of the GH 0.1 was lower than that of the OC. The serum of GH 0.8 showed lower osteocalcin value than the OC (p<0.05). In addition, GOT and GPT levels significantly decreased in all treatment groups. These results indicated that gelatin hydrolysates from pig skin gelatin hydrolysates enhanced BMD and serum biochemical parameters related to bone metabolism. Therefore, the gelatin hydrolysates could be used as a beneficial material to improve bone health.
Keywords
gelatin; collagen; osteoporosis; bone metabolism; pig skin;
Citations & Related Records
Times Cited By KSCI : 4  (Citation Analysis)
Times Cited By Web Of Science : 1  (Related Records In Web of Science)
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