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http://dx.doi.org/10.5851/kosfa.2011.31.1.081

Inhibitory Effect of Polysaccharide from Kefir Grain on the Infection of MA-104 Cell by Human Rotavirus  

Lee, Jong-Ik (Department of Food Science and Biotechnology of Animal Resources, College of Animal Bioscience & Technology, Konkuk University)
Song, Kwang-Young (Department of Public Health, College of Veterinary Medicine, Konkuk University)
Chon, Jung-Whan (Department of Public Health, College of Veterinary Medicine, Konkuk University)
Hyeon, Ji-Yeon (Department of Public Health, College of Veterinary Medicine, Konkuk University)
Seo, Kun-Ho (Department of Public Health, College of Veterinary Medicine, Konkuk University)
Publication Information
Food Science of Animal Resources / v.31, no.1, 2011 , pp. 81-85 More about this Journal
Abstract
The inhibitory effect of a polysaccharide from kefir on human rotavirus infection in MA-104 cells was investigated. The extracted polysaccharide was separated as fraction I in unbound materials and as fractions II, III, and IV in bound materials. Adding polysaccharide fractions II (4.8 mg/mL), III (5.3 mg/mL), and IV (1.4 mg/mL) inhibited the infection of MA-104 cells by human rotavirus. The 50% inhibitory concentrations (IC 50) were 0.075, 0.083, and 0.022 mg/mL, respectively. Based on these results, the kefir polysaccharide has anti-rotavirus activity. In conclusion, a polysaccharide from kefir had more than a 97% inhibition effect against human rotavirus infection in MA-104 cells.
Keywords
kefir; polysaccharide; human rotavirus;
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