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Effect of Bovine Colostrum Factions on the Proliferation of Mouse Splenocytes  

Ha Woel-Kyu (Food Research & Development Lab., Pasteur Milk Co., Ltd.)
Won Do-Hee (Department of Food Biotechnology, Sungkyunkwan University)
Yang Hee-Jin (Department of Food Biotechnology, Sungkyunkwan University)
Hwang Kyung-A (Department of Food Biotechnology, Sungkyunkwan University)
Lee Soo-Won (Department of Food Biotechnology, Sungkyunkwan University)
Publication Information
Food Science of Animal Resources / v.25, no.2, 2005 , pp. 250-256 More about this Journal
Abstract
To investigate the effect of bovine colostral whey fractions on in vitro proliferation of mouse splenocytes, polypeptide fractions were separated from acid whey into 3 fractions depending on molecular weight by ultrafiltration: Fraction I, which contains the polypeptide larger than 10,000 Da, Fraction n, which contains the polypeptide ranging from 1,000 Da to 10,000 Da and Fraction III, which contains the polypeptide smaller than 1,000 Da. Fraction II showed the highest proliferative effect of mouse splenocytes among the colostral whey fractions and this proliferative activity increased in dose dependent manner. Unheated Fraction II and Fraction III showed significantly (p<0.01) higher proliferative effects than others but heated Fraction II showed the highest enhancing effect of mouse splenocyte among heated whey fractions (p<0.01). The supplementation of Fraction II and Fraction m showed greater proliferative effect of mouse splenocytes stimulated by concanavalin A (Con A) than that of whole whey or Fraction L Proliferative effect of mouse splenocytes stimulated by phytohemagglutinin (PHA) was the highest when Fraction II was supplemented Proliferative effect of the colostral whey fractions on mouse splenocytes by stimulation of lipopolysaccharide (LPS) was markedly enhanced by supplementation of Fraction II and Fraction m compared with whole whey and Fraction L It was estimated that colostral whey fraction containing IGF-I positively affected proliferation of mouse splenocyte.
Keywords
colostral whey fraction; splenocyte; proliferation; mitogen;
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