In reality, masonry infill modifies the seismic response of reinforced concrete (r.c.) frame structures by increasing the overall rigidity of structure which results in: increasing of total seismic load value, decreasing of deformations and period of vibration, therefore masonry infill frame structures have larger capacity of absorbing and dissipating seismic energy. The aim of the paper is to explore and assess actual influence of masonry infill on seismic response of r.c. frame structures, to determine whether it's justified to disregard masonry infill influence and to determine appropriate way to consider infill influence by design. This was done by modeling different structures, bare frame structures as well as masonry infill frame structures, while varying masonry infill to r.c. frame stiffness ratio and seismic intensity. Further resistance envelope for those models were created and compared. Different structures analysis have shown that the seismic action on infilled r.c. frame structure is almost always twice as much as seismic action on the same structure with bare r.c. frames, regardless of the seismic intensity. Comparing different models resistance envelopes has shown that, in case of lower stiffness r.c. frame structure, masonry infill (both lower and higher stiffness) increased its lateral load capacity, in average, two times, but in case of higher stiffness r.c. frame structures, influence of masonry infill on lateral load capacity is insignificant. After all, it is to conclude that the optimal structure type depends on its exposure to seismic action and its masonry infill to r.c. frame stiffness ratio.