Ground fissures have a huge effect on the integrity of surface structures. In high-intensity ground fissure regions, however, land resource would be wasted and city building and economic development would be limited if the area avoiding principle was used. In view of this challenge, to reveal the seismic response and seismic failure characteristics of ground fissure sites, a shaking table test on model soil based on a 1:15 scale experiment was carried out. In the test, the spatial distribution characteristics of acceleration response and Arias intensity were obtained for a site exposed to earthquakes with different characteristics. Furthermore, the failure characteristics and damage evolution of the model soil were analyzed. The test results indicated that, with the increase in the earthquake acceleration magnitude, the crack width of the ground fissure enlarged from 0 to 5 mm. The soil of the hanging wall was characterized by earlier cracking and a higher abundance of secondary fissures at 45°. Under strong earthquakes, the model soil, especially the soil near the ground fissure, was severely damaged and exhibited reduced stiffness. As a result, its natural frequency also decreased from 11.41 Hz to 8.05 Hz, whereas the damping ratio increased from 4.8% to 9.1%. Due to the existence of ground fissure, the acceleration was amplified to nearly 0.476 m/s2, as high as 2.38 times of the input acceleration magnitude. The maximum of acceleration and Arias intensity appeared at the fissure zone, which decreased from the main fissure toward both sides, showing hanging wall effects. The seismic intensity, duration and frequency spectrum all had certain effects on the seismic response of the ground fissure site, but their influence degrees were different. The seismic response of the site induced by the seismic wave that had richer low-frequency components and longer duration was larger. The discrepancies of seismic response between the hanging wall and the footwall declined obviously when the magnitude of the earthquake acceleration increased. The research results will be propitious to enhancing the utilizing ratio of the limited landing resource, alleviation of property damages and casualties, and provide a good engineering application foreground.