Kwak, Moon Hwa;Go, Jun;Kim, Ji Eun;Lee, Young Ju;Lee, Seung Hyun;Lee, Hee Seob;Son, Hong Joo;Jung, Young Jin;Hwang, Dae Youn
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Aim of this study was to determine the effect of hydrocolloid membrane containing Styela clava tunic (HCM-SCT) on acute wound of skin. To achieve this, HCM-SCT was developed using the mixture dispersed SCT powder in hydrocolloid (HC), and an alteration on the histology and physiology of wound skin were observed in SD rats after the treatment of HCM-SCT for 11 days. Absorptiveness of HCM-SCT was rapidly increased by 430% at day 1 and then their level was maintained for a period of 4 days, while the surface roughness was higher in HCM-SCT than that of HCM. In animals study, SD rats treated with HCM-SCT did not induce any specific toxicity on the body weight, and the physical function of liver and kidney. The diameter of wound area was shorter in HCM-SCT treated group than these in Gauze (GZ) or HCM treated group. Especially, the group treated with HCM-SCT showed a significantly faster re-epithelization and decrease of epidermis thickness than those treated with HCM alone although a large amount of HC was remained in dermis region of both rats. Furthermore, the level of collagen and tumor growth factor-${\beta}1$ (TGF-${\beta}1$) were greatly increased in HCM-SCT treated group, while the level of angiogenesis-related proteins were significantly recovered to normal level in the same group. Therefore, these results indicate that HCM-SCT having high absorptiveness and tensile strength could accelerate the repair process of acute wound in SD rats through the stimulation of re-epithelization, collagen deposition and angiogenesis.