The purpose of this research is to build a database structure that can be useful for evidence-based medical practices by constructing the knowledge related to oriental medicine in the classical literature knowledge in a form that can utilize new forms of information technology. As a method, "database" is used as a keyword to search published studies in the field of oriental medicine, research is conducted on classic literature knowledge, and studies describing the contents of the data structure are found and analyzed. In conclusion, the original text DB for the preservation of the original texts and the presentation of the supporting texts should include 'Contents Text', 'Tree Structure', 'Herbal Structure', 'Medicine Manufacture', and 'Disease Structure' tables. In order to search, calculate, and automatically extract expressions written in the original text of the old literature, the tool DB should include 'Unit List', 'Capacity Notation List', 'CUI', 'LUI', and 'SUI' tables. In addition, In order to manage integrated knowledge such as herbal, medicine, acupuncture, disease, and literature, and to implement a search function such as comparison of similarity of control composition, the knowledge DB must contain 'dose-controlled medicine name', 'dose-controlled medicine composition', 'relational knowledge', 'knowledge structure', and 'computational knowledge' tables.