Current maintenance operations and integrity checks on a wide array of structures require personnel entry into normally-inaccessible or hazardous areas to perform necessary nondestructive inspections. To gain access for these inspections, structure must be disassembled and removed or personnel must be transported to remote locations. The use of in-situ sensors, coupled with remote interrogation, can be employed to overcome a myriad of inspection impediments stemming from accessibility limitations, complex geometries, the location and depth of hidden damage, and the isolated location of the structure. Furthermore, prevention of unexpected flaw growth and structural failure could be improved if on-board health monitoring systems were used to more regularly assess structural integrity. A research program has been completed to develop and validate Comparative Vacuum Monitoring (CVM) Sensors for surface crack detection. Statistical methods using one-sided tolerance intervals were employed to derive Probability of Detection (POD) levels for a wide array of application scenarios. Multi-year field tests were also conducted to study the deployment and long-term operation of CVM sensors on aircraft. This paper presents the quantitative crack detection capabilities of the CVM sensor, its performance in actual flight environments, and the prospects for structural health monitoring applications on aircraft and other civil structures.