Ozonation is an effective process in providing microbiologically safe drinking water. The operation of the ozonation stage is often based on disinfection criteria which include security factors, such as the CT criterion. This type of ozonation management, which mat include large safety margins, will no longer be possible, since formation of ozonation byproducts has to be avoided. In order to reduce the security factor, a computerized tool to predict with more accuracy inactivation of micro-organisms in the ozonation process has been developed.