Objectives : This study aims to examine the efficacy and application of Cannabis according to its parts. Methods : Contents on efficacy, treatment, and application of Cannabis in Material Medica and other texts of East Asian Medicine were collected and interpreted to deduce each characteristic. Results : Cannabis was found to be applicable to various wind symptoms and wind stroke, various pain and injuries, skin diseases, blockage or leaking of urine or feces, disease related to genitalia and anus, chronic ague, women's disease related to menstruation, birth, pregnancy, and to have the effects of heightening perceptive and sensory organs, detoxification and anesthesia, stimulating hair growth, and eradicating parasites. It drives out wind-heat pathogenic qi, circulates qi and blood, which allowed it to be applied not only to blockages but to symptoms of leakage. In other words, Cannabis was used when both excess and deficiency diseases were present, the former caused by acute blockage and the latter accompanied by stagnation. Conclusions : Based on the findings of this study, future researches on the efficacy and application of Cannabis could be done more systematically. In line with recent trend of wide application of medical Cannabis, we hope for it to be more actively used in the field of East Asian Medicine based on objective evidence.