This paper presents a new operation scheme of UPFC to minimize both generation costs and active power losses in a normal operation state of power system. In a normal operation, cost minimization is a matter of primary concern among operating objectives. This paper considers two kinds of costs, generation costs and transmission losses. The total generation cost of active powers can be minimized by optimal power flow, and active power losses in the transmission system can be also minimized by power flow control of UPFC incorporated with minimization of generation costs. In order to determine amounts of active power reference of each UPFC required for the cost minimization, an iterative optimization algorithm based on the power flow calculation using the decoupled UPFC model is proposed. For verification of the proposed method, intensive studies have been performed on a 3-unit 6-bus system equipped with a UPFC.