The high-power Nd:glass system with five-stage amplifier was designed and its amplification characteristics was studied for developing high-power Nd:glass laser system as an energy driver of inertial confinement fusion(ICF). In order to study the amplification characteristics of remporal and spacial Gaussian laser beam, the dependence of them on pumping efficiency and rod loss were studied and discussed. The output energy of this system using phosphate Nd glass rod(LHG-7,LHG-8) and silicate Nd glass rod(LSG-91H), respectively, was calculated by the computer simulation using Avizonis-Grotbeck and Frantz Nodvik equations. As results of this simulation, it was found that the shorter the risetime of laser pulse, the larger the amplification factor and that the larger peak value of laser pulse, the lower the amplification factor. The output inergies of 179J, 344J, and 7J were obtained by the designed five-stage amplified high-power Nd:glass laser system using glass rods of LHG-7,LHG-8, and LSG-91H, respectively. From the results it was found that the laser system using the LHG-8 glass rod was the most excellent one among the systems and the cross section for stimulated emission of the gain coefficient was essentially important parameter for the amplification characteristics.