Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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The Multifaceted Role of Epithelial Membrane Protein 2 in Cancer: from Biomarker to Therapeutic Target

  • Ji Yun Jang (Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center) ;
  • Mi Kyung Park (Department of Biomedical Science, Hwasung Medi-Science University) ;
  • Chang Hoon Lee (Pharmaceutical Biochemistry, College of Pharmacy, Dongguk University) ;
  • Ho Lee (Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center)
  • Received : 2024.09.09
  • Accepted : 2024.10.07
  • Published : 2024.11.01
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Abstract

Tetraspanin superfamily proteins not only facilitate the trafficking of specific proteins to distinct plasma membrane domains but also influence cell-to-cell and cell-extracellular matrix interactions. Among these proteins, Epithelial Membrane Protein 2 (EMP2), a member of the growth arrest-specific gene 3/peripheral myelin protein 22 (GAS3/PMP22) family, is known to affect key cellular processes. Recent studies have revealed that EMP2 modulates critical signaling pathways and interacts with adhesion molecules and growth factor receptors, underscoring its potential as a biomarker for cancer diagnosis and prognosis. These findings suggest that EMP2 expression patterns could provide valuable insights into tumorigenesis and metastasis. Moreover, EMP2 has emerged as a promising therapeutic target, with approaches aimed at inhibiting or modulating its activity showing potential to disrupt tumor growth and metastasis. This review provides a comprehensive overview of recent advances in understanding the multifaceted roles of EMP2 in cancer, with a focus on its underlying mechanisms and clinical significance.

Keywords

Acknowledgement

This research was supported by a grant from the National Research Foundation (NRF) funded by the Ministry of Science and ICT (RS-2023-00261905 and RS-2024-00441068) and a grant from the National Cancer Center (2010271 and 2410770) of Korean government.

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