Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Experimental Mouse Models and Human Lung Organoid Models for Studying Chronic Obstructive Pulmonary Disease

  • Young Ae Joe (Department of Medical Lifescience, College of Medicine, The Catholic University of Korea) ;
  • Min Ju Lee (Department of Medical Lifescience, College of Medicine, The Catholic University of Korea) ;
  • Hong Seok Choi (Department of Medical Lifescience, College of Medicine, The Catholic University of Korea)
  • Received : 2024.08.23
  • Accepted : 2024.09.30
  • Published : 2024.11.01
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Abstract

Chronic obstructive pulmonary disease (COPD), a leading cause of morbidity and mortality throughout the world, is a highly complicated disease that includes chronic airway inflammation, airway remodeling, emphysema, and mucus hypersecretion. For respiratory function, an intact lung structure is required for efficient air flow through conducting airways and gas exchange in alveoli. Structural changes in small airways and inflammation are major features of COPD. At present, mechanisms involved in the genesis and development of COPD are poorly understood. Currently, there are no effective treatments for COPD. To develop better treatment strategies, it is necessary to study mechanisms of COPD using proper experimental models that can recapitulate distinctive features of human COPD. Therefore, this review will discuss representative established mouse models to investigate inflammatory processes and basic mechanisms of COPD. In addition, human COPD-mimicking human lung organoid models are introduced to help researchers overcome limits of mouse COPD models.

Keywords

Acknowledgement

This research was supported by a grant from the National Research Foundation of Korea grants funded by the Korean government (NRF- 2020R1A2C2006189) and by a grant from the Catholic Medical Center Research Foundation made in the program year of 2024.

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