Journal of Radiopharmaceuticals and Molecular Probes (대한방사성의약품학회지)

Korean Society of Radiopharmaceuticals and Molecular Probes (대한방사성의약품학회)
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ADC and ARC: The Road to Coexistence

  • In Ho Song (Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital) ;
  • Seung Won Kim (Molim, Inc.)
  • Received : 2024.06.12
  • Accepted : 2024.06.24
  • Published : 2024.06.30
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Abstract

Recent advances in disease understanding have led to the discovery of new molecular targets and biomarkers. Therapeutic antibodies targeting specific molecules have been successful in the development of antibody-drug conjugates (ADCs) due to their proven clinical effectiveness and manageable toxicity. Antibody-radionuclide conjugates (ARCs), which use radionuclides instead of drugs, also show promise for their potential therapeutic effects in radioimmunotherapy. Identifying these biomarkers before treatment is increasingly important, leading to personalized medicine. Immuno-positron emission tomography (PET) using radiolabeled monoclonal antibodies is promising for non-invasively assessing target expression and distribution. It can provide valuable information for risk assessment, diagnosis, treatment selection, and evaluation of treatment response. This review discusses recent developments in ADC and ARC and aims to explore opportunities for the simultaneous progress of these drugs.

Keywords

Acknowledgement

이 논문은 과학기술정보통신부 개인기초연구(2022R1F1A1064049)의 지원에 의하여 이루어졌으며 다른 이해관계는 없음.

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