• Nuclear Medicine and Molecular Imaging
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• v.40 no.2
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• pp.90-95
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• 2006

Neuroendocrine tumors (NETs) consist of a heterogeneous group of tumors that are able to uptake neuroamine and/or specific receptors, such as somatostatin receptors, which can play important roles of the localization and treatment of these tumors. When considering therapy with radionuclides, the best radioligand should be carefully investigated. $^{131}I$-MIBG and beta-particle emitter labeled somatostatin analogs are well established radionuclide therapy modalities for NETs. $^{111}In,\;^{90}Y\;and\;^{177}Lu$ radiolabeled somatostatin analogues have been used for treatment of NETs. Further, radionuclide therapy modalities, for example, radioimmunotherapy, radiolabeled peptides such as minigastrin are currently under development and in different phases of clinical investigation. for all radionuclides used for therapy, long-term and survival statistics are not yet available and only partial tumour responses have been obtained using $^{131}I$-MIBG and $^{111}In$-octreotide. Experimental results using $^{90}Y$-DOTA-lanreotide as well as $^{90}Y-DOTA-D-Phe1-Tyr^3-octreotide$ and/or $^{177}Lu-DOTA-Tyr^3-octreotate$ have indicated the possible clinical potential of radionuclides receptor-targeted radiotherapy it may be hoped that the efficacy of radionuclide therapy will be improved by co-administration of chemotherapeutic drugs whose antitumoral properties may be synergistic with that of irradiation.

• Journal of Radiopharmaceuticals and Molecular Probes
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• v.10 no.1
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• pp.63-72
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• 2024

Recent advances in disease understanding have led to the discovery of new molecular targets and biomarkers. Therapeutic antibodies targeting specific molecules have been successful in the development of antibody-drug conjugates (ADCs) due to their proven clinical effectiveness and manageable toxicity. Antibody-radionuclide conjugates (ARCs), which use radionuclides instead of drugs, also show promise for their potential therapeutic effects in radioimmunotherapy. Identifying these biomarkers before treatment is increasingly important, leading to personalized medicine. Immuno-positron emission tomography (PET) using radiolabeled monoclonal antibodies is promising for non-invasively assessing target expression and distribution. It can provide valuable information for risk assessment, diagnosis, treatment selection, and evaluation of treatment response. This review discusses recent developments in ADC and ARC and aims to explore opportunities for the simultaneous progress of these drugs.