International Journal of Stem Cells

Korean Society for Stem Cell Research (한국줄기세포학회)
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The Role of Exosomes from Mesenchymal Stem Cells in Spinal Cord Injury: A Systematic Review

  • Haoyu Wang (Department of Neurology, Affiliated Hospital of Jining Medical University, Jining Medical University) ;
  • Chunxia Zhao (Department of Neurology, Affiliated Hospital of Jining Medical University, Jining Medical University) ;
  • Qingqing Rong (Department of Neurology, Affiliated Hospital of Jining Medical University, Jining Medical University) ;
  • Jinghe Cao (Department of Reproduce, Affiliated Hospital of Jining Medical University, Jining Medical University) ;
  • Hongyi Chen (Department of Gastrointestinal Surgery, Affiliated Hospital of Jining Medical University, Jining Medical University) ;
  • Ruolin Li (Department of Neurology, Affiliated Hospital of Jining Medical University, Jining Medical University) ;
  • Bin Zhang (Institute of Forensic Medicine and Laboratory Medicine, Jining Medical University) ;
  • Peng Xu (Department of Neurology, Affiliated Hospital of Jining Medical University, Jining Medical University)
  • Received : 2023.06.15
  • Accepted : 2023.09.18
  • Published : 2024.08.30
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Abstract

Spinal cord injury (SCI) is a serious nervous system disease that usually leads to the impairment of the motor, sensory, and autonomic nervous functions of the spinal cord, and it places a heavy burden on families and healthcare systems every year. Due to the complex pathophysiological mechanism of SCI and the poor ability of neurons to regenerate, the current treatment scheme has very limited effects on the recovery of spinal cord function. In addition, due to their unique advantages, exosomes can be used as carriers for cargo transport. In recent years, some studies have confirmed that treatment with mesenchymal stem cells (MSCs) can promote the recovery of SCI nerve function. The therapeutic effect of MSCs is mainly related to exosomes secreted by MSCs, and exosomes may have great potential in SCI therapy. In this review, we summarized the repair mechanism of mesenchymal stem cells-derived exosomes (MSCs-Exos) in SCI treatment and discussed the microRNAs related to SCI treatment based on MSCs-Exos and their mechanism of action, which is helpful to further understand the role of exosomes in SCI.

Keywords

Acknowledgement

This research was supported by grants from the National Natural Science Foundation of China (No. 82173371), project tsqn201909192 supported by Tai Shan Young Scholar Foundation of Shandong Province, project ZR2020YQ59 supported by Shandong Provincial Natural Science Foundation, Shandong Province Traditional Chinese Medicine Science (2019-0462) and Technology Development Program and Jining City Key R&D Program (2021YXNS103). The funding body played no role in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript.

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