Fisheries and Aquatic Sciences

The Korean Society of Fisheries and Aquatic Science (한국수산과학회)
권호 표지
DOI QR코드

DOI QR Code

A red seaweed, Polysiphonia morrowii, extract promotes β-cell regeneration in zebrasfish (Danio rerio)

  • Thilini Ranasinghe (Department of Marine Bio and Medical Sciences, Hanseo University) ;
  • Seon-Heui Cha (Department of Marine Bio and Medical Sciences, Hanseo University)
  • Received : 2023.10.03
  • Accepted : 2023.10.20
  • Published : 2024.01.30
Download PDF
⟨ Previous Next ⟩

Abstract

Diabetes Mellitus (DM) is a major health issue increasing worldwide. Currently, nearby half a billion people have diabetes. Two major types of DM that type 1 and type 2-DM have different etiologies but feature a crucial common pathological transition into dysfunction of pancreatic β-cells and consequently leading hyperglycemia and finally go into DM. Therefore, maintaining of β-cells such as preventing β-cells degeneration, and promoting β-cells regeneration and proliferation will be essential approaches in prevention and/or treatment of DM. There are many reports that various types of seaweed control metabolic diseases such as obesity, high blood pressure, and blood sugar control. However, no new drug candidates have been developed yet. Additionally, although seaweed has excellent blood sugar control effects, there is no evidence that it directly proliferates or regenerates beta cells. Therefore, we studied on the promotion of β-cell regeneration by a seaweed, Polysiponia morrowii extract (PME) which preserves β-cells and maintains its function. As a result, it was confirmed that PME directly promotes the proliferation of pancreatic islet β-cells with insulin secretion function in in vivo. Therefore, PME shows potential as a candidate for β-cell regeneration that may play a fundamental role in the treatment of diabetes.

Keywords

Acknowledgement

This research was supported by research supporting program of the Hanseo University in 2022.

References

  1. Brown EM, Allsopp PJ, Magee PJ, Gill CI, Nitecki S, Strain CR, et al. Seaweed and human health. Nutr Rev. 2014;72:205-16. https://doi.org/10.1111/nure.12091
  2. Cha SH, Kim HS, Hwang Y, Jeon YJ, Jun HS. Polysiphonia japonica extract attenuates palmitate-induced toxicity and enhances insulin secretion in pancreatic beta-cells. Oxid Med Cell Longev. 2018;2018:4973851.
  3. Cha SH, Zhang C, Heo SJ, Jun HS. 5-Bromoprotocatechualdehyde combats against palmitate toxicity by inhibiting parkin degradation and reducing ROS-induced mitochondrial damage in pancreatic β-cells. Antioxidants. 2021;10:264.
  4. Chaudhury A, Duvoor C, Reddy Dendi VS, Kraleti S, Chada A, Ravilla R, et al. Clinical review of antidiabetic drugs: implications for type 2 diabetes mellitus management. Front Endocrinol. 2017;8:6.
  5. Curado S, Anderson RM, Jungblut B, Mumm J, Schroeter E, Stainier DYR. Conditional targeted cell ablation in zebrafish: a new tool for regeneration studies. Dev Dyn. 2007;236:1025-35. https://doi.org/10.1002/dvdy.21100
  6. DeFronzo RA, Ferrannini E, Groop L, Henry RR, Herman WH, Holst JJ, et al. Type 2 diabetes mellitus. Nat Rev Dis Primers. 2015;1:15019.
  7. IDF. IDF Diabetes Atlas 10th edition. [Internet]. International Diabetes Federation. 2021 [cited 2022 Feb 15]. https://diabetesatlas.org/
  8. Jayasinghe AMK, Han EJ, Kirindage KGIS, Fernando IPS, Kim EA, Kim J, et al. 3-Bromo-4, 5-dihydroxybenzaldehyde isolated from Polysiphonia morrowii suppresses TNF-α/IFN-γ-stimulated inflammation and deterioration of skin barrier in HaCaT keratinocytes. Mar Drugs. 2022;20:563.
  9. Katsarou A, Gudbjornsdottir S, Rawshani A, Dabelea D, Bonifacio E, Anderson BJ, et al. Type 1 diabetes mellitus. Nat Rev Dis Primers. 2017;3:17016.
  10. Khaliq M, Ko S, Liu Y, Wang H, Sun Y, Solnica-Krezel L, et al. Stat3 regulates liver progenitor cell-driven liver regeneration in zebrafish. Gene Expr. 2018;18:157-70. https://doi.org/10.3727/105221618X15242506133273
  11. Khosla P, Gupta DD, Nagpal RK. Effect of Trigonella foenum graecum (fenugreek) on blood glucose in normal and diabetic rats. Indian J Physiol Pharmacol. 1995;39:173-4.
  12. Kim EA, Han EJ, Kim J, Fernando IPS, Oh JY, Kim KN, et al. Anti-allergic effect of 3,4-dihydroxybenzaldehyde isolated from Polysiphonia morrowii in IgE/BSA-stimulated mast cells and a passive cutaneous anaphylaxis mouse model. Mar Drugs. 2022;20:133.
  13. Martinez MA, Ares I, Martinez M, Lopez-Torres B, Maximiliano JE, Rodriguez JL, et al. Brown marine algae Gongolaria baccata extract protects Caco-2 cells from oxidative stress induced by tert-butyl hydroperoxide. Food Chem Toxicol. 2021;156:112460.
  14. Moro E, Gnugge L, Braghetta P, Bortolussi M, Argenton F. Analysis of beta cell proliferation dynamics in zebrafish. Dev Biol. 2009;332:299-308. https://doi.org/10.1016/j.ydbio.2009.05.576
  15. Roglic G. WHO Global report on diabetes: a summary. Int J Noncommun Dis. 2016;1:3-8. https://doi.org/10.4103/2468-8827.184853
  16. Sharifuddin Y, Chin YX, Lim PE, Phang SM. Potential bioactive compounds from seaweed for diabetes management. Mar Drugs. 2015;13:5447-91. https://doi.org/10.3390/md13085447
  17. Silva J, Alves C, Pinteus S, Mendes S, Pedrosa R. Neuroprotective effects of seaweeds against 6-hydroxidopamine-induced cell death on an in vitro human neuroblastoma model. BMC Complement Altern Med. 2018;18:58.
  18. Tehrani Z, Lin S. Endocrine pancreas development in zebrafish. Cell Cycle. 2011;10:3466-72. https://doi.org/10.4161/cc.10.20.17764
  19. Zang L, Maddison LA, Chen W. Zebrafish as a model for obesity and diabetes. Front Cell Dev Biol. 2018;6:91.