Acknowledgement
The authors thank Professor (Dr.) Eun Mi Park (Hannam University, Daejeon, Republic of Korea) for providing the HaCaT cell line and technical advice.
References
- Yang G, Seok JK, Kang HC, Cho YY, Lee HS, Lee JY. Skin barrier abnormalities and immune dysfunction in atopic dermatitis. Int J Mol Sci 2020;21:2867.
- Gittler JK, Shemer A, Suarez-Farinas M, Fuentes-Duculan J, Gulewicz KJ, Wang CQ, Mitsui H, Cardinale I, de Guzman Strong C, Krueger JG, et al. Progressive activation of T(H)2/T(H)22 cytokines and selective epidermal proteins characterizes acute and chronic atopic dermatitis. J Allergy Clin Immunol 2012;130:1344-54. https://doi.org/10.1016/j.jaci.2012.07.012
- Leung DY, Guttman-Yassky E. Deciphering the complexities of atopic dermatitis: shifting paradigms in treatment approaches. J Allergy Clin Immunol 2014;134:769-79. https://doi.org/10.1016/j.jaci.2014.08.008
- Renert-Yuval Y, Thyssen JP, Bissonnette R, Bieber T, Kabashima K, Hijnen D, Guttman-Yassky E. Biomarkers in atopic dermatitis-a review on behalf of the International Eczema Council. J Allergy Clin Immunol 2021;147:1174-1190.e1. https://doi.org/10.1016/j.jaci.2021.01.013
- Luger T, Amagai M, Dreno B, Dagnelie MA, Liao W, Kabashima K, Schikowski T, Proksch E, Elias PM, Simon M, et al. Atopic dermatitis: role of the skin barrier, environment, microbiome, and therapeutic agents. J Dermatol Sci 2021;102:142-57. https://doi.org/10.1016/j.jdermsci.2021.04.007
- Wollenberg A, Barbarot S, Bieber T, Christen-Zaech S, Deleuran M, Fink-Wagner A, Gieler U, Girolomoni G, Lau S, Muraro A, et al. Consensus-based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part I. J Eur Acad Dermatol Venereol 2018;32:657-82. https://doi.org/10.1111/jdv.14891
- Ye X, Jiang Y. Phytochemicals in Goji Berries. Boca Raton (FL): CRC Press; 2020.
- Yao R, Heinrich M, Zhao X, Wang Q, Wei J, Xiao P. What's the choice for goji: Lycium barbarum L. or L. chinense Mill.? J Ethnopharmacol 2021;276:114185.
- Zhao XQ, Guo S, Lu YY, Hua Y, Zhang F, Yan H, Shang EX, Wang HQ, Zhang WH, Duan JA. Lycium barbarum L. leaves ameliorate type 2 diabetes in rats by modulating metabolic profiles and gut microbiota composition. Biomed Pharmacother 2020;121:109559.
- Mocan A, Zengin G, Simirgiotis M, Schafberg M, Mollica A, Vodnar DC, Crisan G, Rohn S. Functional constituents of wild and cultivated Goji (L. barbarum L.) leaves: phytochemical characterization, biological profile, and computational studies. J Enzyme Inhib Med Chem 2017;32:153-68. https://doi.org/10.1080/14756366.2016.1243535
- Ma JF, Zhang H, Teh SS, Wang CW, Zhang Y, Hayford F, Wang L, Ma T, Dong Z, Zhang Y, et al. Goji berries as a potential natural antioxidant medicine: an insight into their molecular mechanisms of action. Oxid Med Cell Longev 2019;2019:2437397.
- Paik S, Lee J, Yun TS, Park YC, Lee B, Son S, Ju J. Effects of planting density and cutting height on production of leaves for processing raw materials in goji berry. Korean J Med Crop Sci 2020;28:136-41. https://doi.org/10.7783/KJMCS.2020.28.2.136
- Nurhayati N, Suendo V. Isolation of chlorophyll a from spinach leaves and modification of center ion with Zn2+: study on its optical stability. J Matematika Sains 2011;16:65-70.
- Solymosi K, Mysliwa-Kurdziel B. Chlorophylls and their derivatives used in food industry and medicine. Mini Rev Med Chem 2017;17:1194-222. https://doi.org/10.2174/1389557516666161004161411
- Porrarud S, Pranee A. Microencapsulation of Zn-chlorophyll pigment from Pandan leaf by spray drying and its characteristic. Int Food Res J 2010;17:1031-42.
- Kim JE, Bae SM, Nam YR, Bae EY, Ly SY. Antioxidant activity of ethanol extract of Lycium barbarum's leaf with removal of chlorophyll. J Nutr Health 2019;52:26-35. https://doi.org/10.4163/jnh.2019.52.1.26
- Bae SM, Kim JE, Bae EY, Kim KA, Ly SY. Anti-inflammatory effects of fruit and leaf extracts of Lycium barbarum in lipopolysaccharide-stimulated RAW264. 7 cells and animal model. J Nutr Health 2019;52:129-38. https://doi.org/10.4163/jnh.2019.52.2.129
- Nam KY, Go YE, Lee SY, Lee JS. A study on natural dye having the effects on the atopic dermatitis-Juniperus chinensis heartwood extract. Fibers Polym 2013;14:2045-53. https://doi.org/10.1007/s12221-013-2045-8
- Cha KJ, Im MA, Gu A, Kim DH, Lee D, Lee JS, Lee JS, Kim IS. Inhibitory effect of Patrinia scabiosifolia Link on the development of atopic dermatitis-like lesions in human keratinocytes and NC/Nga mice. J Ethnopharmacol 2017;206:135-43. https://doi.org/10.1016/j.jep.2017.03.045
- Tice RR, Agurell E, Anderson D, Burlinson B, Hartmann A, Kobayashi H, Miyamae Y, Rojas E, Ryu JC, Sasaki YF. Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing. Environ Mol Mutagen 2000;35:206-21. https://doi.org/10.1002/(SICI)1098-2280(2000)35:3<206::AID-EM8>3.0.CO;2-J
- Trautmann A, Akdis M, Schmid-Grendelmeier P, Disch R, Brocker EB, Blaser K, Akdis CA. Targeting keratinocyte apoptosis in the treatment of atopic dermatitis and allergic contact dermatitis. J Allergy Clin Immunol 2001;108:839-46. https://doi.org/10.1067/mai.2001.118796
- Baugh JA, Bucala R. Mechanisms for modulating TNF alpha in immune and inflammatory disease. Curr Opin Drug Discov Devel 2001;4:635-50.
- Choi Y, Kim MS, Hwang JK. Inhibitory effects of panduratin A on allergy-related mediator production in rat basophilic leukemia mast cells. Inflammation 2012;35:1904-15. https://doi.org/10.1007/s10753-012-9513-y
- Peng W, Novak N. Pathogenesis of atopic dermatitis. Clin Exp Allergy 2015;45:566-74. https://doi.org/10.1111/cea.12495
- Otsuka A, Nomura T, Rerknimitr P, Seidel JA, Honda T, Kabashima K. The interplay between genetic and environmental factors in the pathogenesis of atopic dermatitis. Immunol Rev 2017;278:246-62. https://doi.org/10.1111/imr.12545
- Danso MO, van Drongelen V, Mulder A, van Esch J, Scott H, van Smeden J, El Ghalbzouri A, Bouwstra JA. TNF-α and Th2 cytokines induce atopic dermatitis-like features on epidermal differentiation proteins and stratum corneum lipids in human skin equivalents. J Invest Dermatol 2014;134:1941-50. https://doi.org/10.1038/jid.2014.83
- Diehl S, Rincon M. The two faces of IL-6 on Th1/Th2 differentiation. Mol Immunol 2002;39:531-6. https://doi.org/10.1016/S0161-5890(02)00210-9
- Nguyen SM, Rupprecht CP, Haque A, Pattanaik D, Yusin J, Krishnaswamy G. Mechanisms governing anaphylaxis: inflammatory cells, mediators, endothelial gap junctions and beyond. Int J Mol Sci 2021;22:7785.
- Ji H, Li XK. Oxidative stress in atopic dermatitis. Oxid Med Cell Longev 2016;2016:2721469.
- Tsukahara H, Shibata R, Ohshima Y, Todoroki Y, Sato S, Ohta N, Hiraoka M, Yoshida A, Nishima S, Mayumi M. Oxidative stress and altered antioxidant defenses in children with acute exacerbation of atopic dermatitis. Life Sci 2003;72:2509-16. https://doi.org/10.1016/S0024-3205(03)00145-0
- Omata N, Tsukahara H, Ito S, Ohshima Y, Yasutomi M, Yamada A, Jiang M, Hiraoka M, Nambu M, Deguchi Y, et al. Increased oxidative stress in childhood atopic dermatitis. Life Sci 2001;69:223-8. https://doi.org/10.1016/S0024-3205(01)01124-9
- Werfel T, Allam JP, Biedermann T, Eyerich K, Gilles S, Guttman-Yassky E, Hoetzenecker W, Knol E, Simon HU, Wollenberg A, et al. Cellular and molecular immunologic mechanisms in patients with atopic dermatitis. J Allergy Clin Immunol 2016;138:336-49. https://doi.org/10.1016/j.jaci.2016.06.010
- Proksch E, Folster-Holst R, Jensen JM. Skin barrier function, epidermal proliferation and differentiation in eczema. J Dermatol Sci 2006;43:159-69. https://doi.org/10.1016/j.jdermsci.2006.06.003
- Kawakami T, Ando T, Kimura M, Wilson BS, Kawakami Y. Mast cells in atopic dermatitis. Curr Opin Immunol 2009;21:666-78. https://doi.org/10.1016/j.coi.2009.09.006
- Kritas SK, Saggini A, Varvara G, Murmura G, Caraffa A, Antinolfi P, Toniato E, Pantalone A, Neri G, Frydas S, et al. Impact of mast cells on the skin. Int J Immunopathol Pharmacol 2013;26:855-9. https://doi.org/10.1177/039463201302600403
- Saeki H, Tamaki K. Thymus and activation regulated chemokine (TARC)/CCL17 and skin diseases. J Dermatol Sci 2006;43:75-84. https://doi.org/10.1016/j.jdermsci.2006.06.002
- Nakazato J, Kishida M, Kuroiwa R, Fujiwara J, Shimoda M, Shinomiya N. Serum levels of Th2 chemokines, CCL17, CCL22, and CCL27, were the important markers of severity in infantile atopic dermatitis. Pediatr Allergy Immunol 2008;19:605-13. https://doi.org/10.1111/j.1399-3038.2007.00692.x
- Masci A, Carradori S, Casadei MA, Paolicelli P, Petralito S, Ragno R, Cesa S. Lycium barbarum polysaccharides: extraction, purification, structural characterisation and evidence about hypoglycaemic and hypolipidaemic effects. A review. Food Chem 2018;254:377-89. https://doi.org/10.1016/j.foodchem.2018.01.176
- Zhou ZQ, Xiao J, Fan HX, Yu Y, He RR, Feng XL, Kurihara H, So KF, Yao XS, Gao H. Polyphenols from wolfberry and their bioactivities. Food Chem 2017;214:644-54. https://doi.org/10.1016/j.foodchem.2016.07.105
- Jin M, Huang Q, Zhao K, Shang P. Biological activities and potential health benefit effects of polysaccharides isolated from Lycium barbarum L. Int J Biol Macromol 2013;54:16-23. https://doi.org/10.1016/j.ijbiomac.2012.11.023
- Tian X, Liang T, Liu Y, Ding G, Zhang F, Ma Z. Extraction, structural characterization, and biological functions of Lycium Barbarum polysaccharides: a review. Biomolecules 2019;9:389.
- Cheng J, Zhou ZW, Sheng HP, He LJ, Fan XW, He ZX, Sun T, Zhang X, Zhao RJ, Gu L, et al. An evidence-based update on the pharmacological activities and possible molecular targets of Lycium barbarum polysaccharides. Drug Des Devel Ther 2014;9:33-78.