Nutrition Research and Practice

The Korean Nutrition Society (한국영양학회)
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Mentha canadensis attenuates adiposity and hepatic steatosis in high-fat diet-induced obese mice

  • Youngji Han (Biological Clock-based Anti-aging Convergence Regional Leading Research Center of National Research Foundation of Korea, Korea University) ;
  • Ji-Young Choi (Department of Food and Nutrition, Chosun University) ;
  • Eun-Young Kwon (Department of Food Science and Nutrition, Kyungpook National University)
  • Received : 2023.07.12
  • Accepted : 2023.08.14
  • Published : 2023.10.01
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Abstract

BACKGROUND/OBJECTIVES: Obesity is a major risk factor for metabolic syndrome, a global public health problem. Mentha canadensis (MA), a traditional phytomedicine and dietary herb used for centuries, was the focus of this study to investigate its effects on obesity. MATERIALS/METHODS: Thirty-five male C57BL/6J mice were randomly divided into 2 groups and fed either a normal diet (ND, n = 10) or a high-fat diet (HFD, n = 25) for 4 weeks to induce obesity. After the obesity induction period, the HFD-fed mice were randomly separated into 2 groups: one group continued to be fed HFD (n = 15, HFD group), while the other group was fed HFD with 1.5% (w/w) MA ethanol extract (n = 10, MA group) for 13 weeks. RESULTS: The results showed that body and white adipose tissue (WAT) weights were significantly decreased in the MA-supplemented group compared to the HFD group. Additionally, MA supplementation enhanced energy expenditure, leading to improvements in plasma lipids, cytokines, hepatic steatosis, and fecal lipids. Furthermore, MA supplementation regulated lipid-metabolism-related enzyme activity and gene expression, thereby suppressing lipid accumulation in the WAT and liver. CONCLUSIONS: These findings indicate that MA has the potential to improve diet-induced obesity and its associated complications, including adiposity, dyslipidemia, hepatic steatosis, and inflammation.

Keywords

Acknowledgement

This work was carried out with the support of the 'Cooperative Research Program for Agriculture Science and Technology Development' (Project No. RS-2022-RD010283) from the Rural Development Administration of the Republic of Korea, and the National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) (No. RS-2023-00213596).

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