Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Current Status and Future Trends of Cold Atmospheric Plasma as an Oncotherapy

  • Xiaofeng Dai (The First Affiliated Hospital of Xi'an Jiaotong University) ;
  • Jiale Wu (The First Affiliated Hospital of Xi'an Jiaotong University) ;
  • Lianghui Lu (The First Affiliated Hospital of Xi'an Jiaotong University) ;
  • Yuyu Chen (The First Affiliated Hospital of Xi'an Jiaotong University)
  • Received : 2023.02.14
  • Accepted : 2023.04.25
  • Published : 2023.09.01
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Abstract

Cold atmospheric plasma (CAP), a redox modulation tool, is capable of inhibiting a wide spectrum of cancers and has thus been proposed as an emerging onco-therapy. However, with incremental successes consecutively reported on the anticancer efficacy of CAP, no consensus has been made on the types of tumours sensitive to CAP due to the different intrinsic characteristics of the cells and the heterogeneous design of CAP devices and their parameter configurations. These factors have substantially hindered the clinical use of CAP as an oncotherapy. It is thus imperative to clarify the tumour types responsive to CAP, the experimental models available for CAP-associated investigations, CAP administration strategies and the mechanisms by which CAP exerts its anticancer effects with the aim of identifying important yet less studied areas to accelerate the process of translating CAP into clinical use and fostering the field of plasma oncology.

Keywords

Acknowledgement

This work was supported by the National Natural Science Foundation of China (Grant No. 81972789) and Fundamental Research Funds for the Central Universities (Grant No. JUSRP22011). The funding bodies played no role in the design of the study; collection, analysis, and interpretation of data; or in manuscript preparation.

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