References
- Sullivan SA, Kounali D, Cannon M, David AS, Fletcher PC, Holmans P, et al. A population-based cohort study examining the incidence and impact of psychotic experiences from childhood to adulthood, and prediction of psychotic disorder. The American Journal of Psychiatry. 2020;177(4):308-317. https://doi.org/10.1176/appi.ajp.2019.19060654
- Yoon SJ, Kim YE, Lee HG, Chung SG, Choi MM, Ha KH, et al. A survey on the medical system for people with severe and mental disorders. Seoul: National Human Rights Commission of Korea; 2019 Dec. Report No.: 11-1620000-000764-01.
- Ruggeri M, Leese M, Thornicroft G, Bisoffi G, Tansella M. Definition and prevalence of severe and persistent mental illness. The British Journal of Psychiatry. 2000;177(2):149-155. https://doi.org/10.1192/bjp.177.2.149
- Joa I, Gisselgard J, Bronnick K, McGlashan T, Johannessen JO. Primary prevention of psychosis through interventions in the symptomatic prodromal phase, a pragmatic Norwegian Ultra High Risk study. BMC Psychiatry. 2015;15:89. https://doi.org/10.1186/s12888-015-0470-5
- Rus-Calafell M, Schneider S. Are we there yet?!-a literature review of recent digital technology advances for the treatment of early psychosis. Mhealth. 2020;6:3. https://doi.org/10.21037/mhealth.2019.09.14
- American Psychiatric Association. Diagnostic and statistical manual of mental disorders: DSM-5. 5th ed. Washington, DC: American Psychiatric Publishing; 2013. p. 87-122.
- Alvarez-Jimenez M, Priede A, Hetrick SE, Bendall S, Killackey E, Parker AG, et al. Risk factors for relapse following treatment for first episode psychosis: A systematic review and meta-analysis of longitudinal studies. Schizophrenia Research. 2012;139(1-3):116-128. https://doi.org/10.1016/j.schres.2012.05.007
- Ben-Zeev D, Chander A, Tauscher J, Buck B, Nepal S, Campbell A, et al. A smartphone intervention for people with serious mental illness: Fully remote randomized controlled trial of CORE. Journal of Medical Internet Research. 2021;23(11):e29201. https://doi.org/10.2196/29201
- World Health Organization (WHO). mhGAP training manuals for the mhGAP intervention guide for mental, neurological and substance use disorders in non-specialized health settings, version 2.0 ( for field testing). Geneva: World Health Organization; 2017. Report No.: WHO/MSD/MER/17.6.
- Huhn M, Nikolakopoulou A, Schneider-Thoma J, Krause M, Samara M, Peter N, et al. Comparative efficacy and tolerability of 32 oral antipsychotics for the acute treatment of adults with multi-episode schizophrenia: A systematic review and network meta-analysis. Lancet. 2019;394(10202):939-951. https://doi.org/10.1016/S0140-6736(19)31135-3
- Bilder RM, Goldman RS, Volavka J, Czobor P, Hoptman M, Sheitman B, et al. Neurocognitive effects of clozapine, olanzapine, risperidone, and haloperidol in patients with chronic schizophrenia or schizoaffective disorder. The American Journal of Psychiatry. 2002;159(6):1018-1028. https://doi.org/10.1176/appi.ajp.159.6.1018
- Larson MK, Walker EF, Compton MT. Early signs, diagnosis and therapeutics of the prodromal phase of schizophrenia and related psychotic disorders. Expert Review of Neurotherapeutics. 2010;10(8):1347-1359. https://doi.org/10.1586/ern.10.93
- Guhne U, Weinmann S, Riedel-Heller SG, Becker T. Psychosocial therapies in severe mental illness: Update on evidence and recommendations. Current Opinion in Psychiatry. 2020;33(4):414-421. https://doi.org/10.1097/YCO.0000000000000618
- Kreyenbuhl J, Buchanan RW, Dickerson FB, Dixon LB; Schizophrenia Patient Outcomes Research Team (PORT). The Schizophrenia Patient Outcomes Research Team (PORT): Updated treatment recommendations 2009. Schizophrenia Bulletin. 2010;36(1):94-103. https://doi.org/10.1093/schbul/sbp130
- Lee SY, Chae SM, Jeon JA, Yoon SM, Cha MR, Jung JW, et al. Strategies for securing the local mental health promotion service supply system - focusing on the management of severe mental illness in the community. Sejong: Korea Institute for Health and Social Affairs; 2018 Dec. Report No.: Research Monographs 2018-26.
- Lee YM. National mental health survey. Seoul: National Center for Mental Health (KR); 2021 Dec. Report No.: 11-1352629-000065-01.
- Corrigan PW, Druss BG, Perlick DA. The impact of mental illness stigma on seeking and participating in mental health care. Psychological Science in the Public Interest. 2014;15(2):37-70. https://doi.org/10.1177/1529100614531398
- Murray E, Hekler EB, Andersson G, Collins LM, Doherty A, Hollis C, et al. Evaluating digital health interventions: Key questions and approaches. American Journal of Preventive Medicine. 2016;51(5):843-851. https://doi.org/10.1016/j.amepre.2016.06.008
- Bell I, Pot-Kolder RMCA, Wood SJ, Nelson B, Acevedo N, Stainton A, et al. Digital technology for addressing cognitive impairment in recent-onset psychosis: A perspective. Schizophrenia Research: Cognition. 2022;28:100247. https://doi.org/10.1016/j.scog.2022.100247
- Moulin T, Dobson J, Hixson JD, Arvanitis TN. Digital Health: The journal's pioneering journey 6 years on. Digital Health. 2021;7:20552076211034034. https://doi.org/10.1177/20552076211034034
- Krzystanek M, Borkowski M, Skalacka K, Krysta K. A telemedicine platform to improve clinical parameters in paranoid schizophrenia patients: Results of a one-year randomized study. Schizophrenia Research. 2019;204:389-396. https://doi.org/10.1016/j.schres.2018.08.016
- Garety P, Ward T, Emsley R, Greenwood K, Freeman D, Fowler D, et al. Effects of SlowMo, a blended digital therapy targeting reasoning, on paranoia among people with psychosis: A randomized clinical trial. JAMA Psychiatry. 2021;78(7):714-725. https://doi.org/10.1001/jamapsychiatry.2021.0326
- Dellazizzo L, Potvin S, Phraxayavong K, Dumais A. Oneyear randomized trial comparing virtual reality-assisted therapy to cognitive-behavioral therapy for patients with treatment-resistant schizophrenia. NPJ Schizophrenia. 2021;7(1):9. https://doi.org/10.1038/s41537-021-00139-2
- Gottlieb JD, Gidugu V, Maru M, Tepper MC, Davis MJ, Greenwold J, et al. Randomized controlled trial of an internet cognitive behavioral skills-based program for auditory hallucinations in persons with psychosis. Psychiatric Rehabilitation Journal. 2017;40(3):283-292. https://doi.org/10.1037/prj0000258
- Depp CA, Perivoliotis D, Holden J, Dorr J, Granholm EL. Single-session mobile-augmented intervention in serious mental illness: A three-arm randomized controlled trial. Schizophrenia Bulletin. 2019;45(4):752-762. https://doi.org/10.1093/schbul/sby135
- Marono Souto Y, Vazquez Campo M, Diaz Llenderrozas F, Rodriguez lvarez M, Mateos R, Garcia Caballero A. Randomized clinical trial with e-MotionalTraining® 1.0 for social cognition rehabilitation in schizophrenia. Frontiers in Psychiatry. 2018;9:40. https://doi.org/10.3389/fpsyt.2018.00040
- Cullen BA, Rodriguez K, Eaton WW, Mojtabai R, Von Mach T, Ybarra ML. Clinical outcomes from the texting for relapse prevention (T4RP) in schizophrenia and schizoaffective disorder study. Psychiatry Research. 2020;292:113346. https://doi.org/10.1016/j.psychres.2020.113346
- Naslund JA, Aschbrenner KA. Digital technology for health promotion: Opportunities to address excess mortality in persons living with severe mental disorders. Evidence Based Mental Health. 2019;22(1):17-22. https://doi.org/10.1136/ebmental-2018-300034
- Chivilgina O, Elger BS, Jotterand F. Digital technologies for schizophrenia management: A descriptive review. Science and Engineering Ethics. 2021;27(2):25. https://doi.org/10.1007/s11948-021-00302-z
- Kim SK, Lee M, Jeong H, Jang YM. Effectiveness of mobile applications for patients with severe mental illness: A meta-analysis of randomized controlled trials. Japan Journal of Nursing Science. 2022;19(3):e12476. https://doi.org/10.1111/jjns.12476
- Mohr DC, Azocar F, Bertagnolli A, Choudhury T, Chrisp P, Frank R, et al.; Banbury Forum on Digital Mental Health. Banbury forum consensus statement on the path forward for digital mental health treatment. Psychiatric Services. 2021;72(6):677-683. https://doi.org/10.1176/appi.ps.202000561
- Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, et al. Cochrane handbook for systematic reviews of interventions. 2nd ed. Chichester (WS): John Wiley & Sons; 2019. p. 321-374.
- Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. BMJ. 2021;372:n71. https://doi.org/10.1136/bmj.n71
- Bidwell S, Jensen MF. Etext on health technology assessment (HTA) information resources. Chapter 3: Using a search protocol to identify sources of information: The COSI model [Internet]. Bethesda: National Library of Medicine (US); c2003 [cited 2022 May 20]. Available from: https://www.nlm.nih. gov/archive/20060905/nichsr/ehta/chapter3.html#COSI
- Higgins JP, Altman DG, Gotzsche PC, Juni P, Moher D, Oxman AD, et al. The Cochrane Collaboration's tool for assessing risk of bias in randomised trials. BMJ. 2011;343:d5928. https://doi.org/10.1136/bmj.d5928
- Kim SY, Park DA, Seo HJ, Shin SS, Lee SJ, Lee M, et al. Health technology assessment methodology: Systematic review. Seoul: National Evidence-based Healthcare Collaborating Agency (KR); 2020. p. 131-132.
- Cohen J. Statistical power analysis for the behavioral sciences. 2nd ed. Hillsdale (NJ): Lawrence Eribaum Associates; 1988. p. 22.
- Bell IH, Rossell SL, Farhall J, Hayward M, Lim MH, Fielding-Smith SF, et al. Pilot randomised controlled trial of a brief coping-focused intervention for hearing voices blended with smartphone-based ecological momentary assessment and intervention (SAVVy): Feasibility, acceptability and preliminary clinical outcomes. Schizophrenia Research. 2020;216:479-487. https://doi.org/10.1016/j.schres.2019.10.026
- Ben-Zeev D, Brian RM, Jonathan G, Razzano L, Pashka N, Carpenter-Song E, et al. Mobile health (mHealth) versus clinic-based group intervention for people with serious mental illness: A randomized controlled trial. Psychiatric Services. 2018;69(9):978-985. https://doi.org/10.1176/appi.ps.201800063
- Pot-Kolder RMCA, Geraets CNW, Veling W, van Beilen M, Staring ABP, Gijsman HJ, et al. Virtual-reality-based cognitive behavioural therapy versus waiting list control for paranoid ideation and social avoidance in patients with psychotic disorders: A single-blind randomised controlled trial. Lancet Psychiatry. 2018;5(3):217-226. https://doi.org/10.1016/S2215-0366(18)30053-1
- Lewis S, Ainsworth J, Sanders C, Stockton-Powdrell C, Machin M, Whelan P, et al. Smartphone-enhanced symptom management in psychosis: Open, randomized controlled trial. Journal of Medical Internet Research. 2020;22(8):e17019. https://doi.org/10.2196/17019
- Craig TK, Rus-Calafell M, Ward T, Leff JP, Huckvale M, Howarth E, et al. AVATAR therapy for auditory verbal hallucinations in people with psychosis: A single-blind, randomised controlled trial. Lancet Psychiatry. 2018;5(1):31-40. https://doi.org/10.1016/S2215-0366(17)30427-3 Erratum in: Lancet Psychiatry. 2018;5(1):e1.
- Ghaemi SN, Sverdlov O, van Dam J, Campellone T, Gerwien R. A smartphone-based intervention as an adjunct to standard-of-care treatment for schizophrenia: Randomized controlled trial. JMIR Formative Research. 2022;6(3):e29154. https://doi.org/10.2196/29154
- Mojtabai R, Fochtmann L, Chang SW, Kotov R, Craig TJ, Bromet E. Unmet need for mental health care in schizophrenia: An overview of literature and new data from a first-admission study. Schizophrenia Bulletin. 2009;35(4):679-695. https://doi.org/10.1093/schbul/sbp045
- Cugelman B. Gamification: What it is and why it matters to digital health behavior change developers. JMIR Serious Games. 2013;1(1):e3. https://doi.org/10.2196/games.3139
- National Collaborating Centre for Mental Health (GB). Psychosis and schizophrenia in adults: Treatment and management. Updated ed. London: National Collaborating Centre for Mental Health (GB); 2014. p. 221-222.
- Jauhar S, Laws KR, McKenna PJ. CBT for schizophrenia: A critical viewpoint. Psychological Medicine. 2019;49(8):1233- 1236. https://doi.org/10.1017/S0033291718004166
- Bighelli I, Salanti G, Huhn M, Schneider-Thoma J, Krause M, Reitmeir C, et al. Psychological interventions to reduce positive symptoms in schizophrenia: Systematic review and network meta-analysis. World Psychiatry. 2018;17(3):316-329. https://doi.org/10.1002/wps.20577
- Killaspy H, Harvey C, Brasier C, Brophy L, Ennals P, Fletcher J, et al. Community-based social interventions for people with severe mental illness: A systematic review and narrative synthesis of recent evidence. World Psychiatry. 2022;21(1):96-123. https://doi.org/10.1002/wps.20940
- Alvarez-Jimenez M, Alcazar-Corcoles MA, Gonzalez-Blanch C, Bendall S, McGorry PD, Gleeson JF. Online, social media and mobile technologies for psychosis treatment: A systematic review on novel user-led interventions. Schizophrenia Research. 2014;156(1):96-106. https://doi.org/10.1016/j.schres.2014.03.021
- Torous J, Bucci S, Bell IH, Kessing LV, Faurholt-Jepsen M, Whelan P, et al. The growing field of digital psychiatry: Current evidence and the future of apps, social media, chatbots, and virtual reality. World Psychiatry. 2021;20(3):318-335. https://doi.org/10.1002/wps.20883
- Ben-Zeev D, Brenner CJ, Begale M, Duffecy J, Mohr DC, Mueser KT. Feasibility, acceptability, and preliminary efficacy of a smartphone intervention for schizophrenia. Schizophrenia Bulletin. 2014;40(6):1244-1253. https://doi.org/10.1093/schbul/sbu033
- Torous J, Nicholas J, Larsen ME, Firth J, Christensen H. Clinical review of user engagement with mental health smartphone apps: Evidence, theory and improvements. Evidence Based Mental Health. 2018;21(3):116-119. https://doi.org/10.1136/eb-2018-102891
- Steare T, O'Hanlon P, Eskinazi M, Osborn D, Lloyd-Evans B, Jones R, et al. Smartphone-delivered self-management for first-episode psychosis: The ARIES feasibility randomised controlled trial. BMJ Open. 2020;10(8):e034927. https://doi.org/10.1136/bmjopen-2019-034927
- Hansson L, Hedner T, Dahlof B. Prospective randomized open blinded end-point (PROBE) study. A novel design for intervention trials. Prospective Randomized Open Blinded End-Point. Blood Pressure. 1992;1(2):113-119. https://doi.org/10.3109/08037059209077502
- Sverdlov O, van Dam J, Hannesdottir K, Thornton-Wells T. Digital therapeutics: An integral component of digital innovation in drug development. Clinical Pharmacology and Therapeutics. 2018;104(1):72-80. https://doi.org/10.1002/cpt.1036
- Kim SY, Park DA, Seo HJ, Shin SS, Lee SJ, Lee M, et al. Health technology assessment methodology: Systematic review. Seoul: National Evidence-based Healthcare Collaborating Agency (KR); 2020. p. 140.