Journal of the Korean Magnetic Resonance Society (한국자기공명학회논문지)

Korean Magnetic Resonance Society (한국자기공명학회)
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Backbone assignment of human Hoxc9DBD

  • Ja-Shil Hyun (College of Pharmacy and Gachon Institute of Pharmaceutical Sciences, Gachon University) ;
  • Sung Jean Park (College of Pharmacy and Gachon Institute of Pharmaceutical Sciences, Gachon University)
  • Received : 2023.11.20
  • Accepted : 2023.12.04
  • Published : 2023.12.20
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Abstract

Hoxc, or the Homeobox C cluster, is a group of genes that play a crucial role in embryonic development, particularly in patterning the body along the anterior-posterior axis. These genes encode transcription factors, which are proteins that bind to DNA and regulate the expression of other genes. Hoxc9 is specifically involved in the development of the skeletal system, nervous system, and adipose tissue. Hoxc9 overexpression has been linked to the development of various cancers such as leukemia and breast cancer. Here, we assigned the chemical shifts Hoxc9 DNA binding domain (DBD) using heteronuclear NMR techniques. The helical regions of Hoxc9 DBD correspond to the residues T200 - F213 (Helix I), T218 - L229 (Helix II), and T232 - K249 (Helix III). Our result would be helpful for studing the molecular interactions of the Hoxc9 DBD and other proteins.

Keywords

Acknowledgement

This work was supported by grants from the National Research Foundation of Korea (NRF-2021R1F1A1061607 and 2020R1A6A1A0304370812).

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