Journal of the Korean Applied Science and Technology (한국응용과학기술학회지)

The Korean Society of Applied Science and Technology (한국응용과학기술학회)
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Therapeutic Effects of LED Fusion of Two Wavelength Bands on Atopic Dermatitis of NC/Nga Mice

융합 LED 광선치료가 아토피 피부염에 미치는 영향

  • Lee, Sangmin (Department of Laboratory Aniaml Medicine, College of Veterinary Medicine, Jeonbuk National University) ;
  • Choi, Ji-Hye (Department of Laboratory Aniaml Medicine, College of Veterinary Medicine, Jeonbuk National University) ;
  • Koo, Bon-Jun (Zero 9 material Co. LTD.) ;
  • Kwon, Jungkee (Department of Laboratory Aniaml Medicine, College of Veterinary Medicine, Jeonbuk National University)
  • 이상민 (전북대학교 수의과대학 실험동물의학교실) ;
  • 최지혜 (전북대학교 수의과대학 실험동물의학교실) ;
  • 구본준 ((주)제로나인 메트리얼) ;
  • 권중기 (전북대학교 수의과대학 실험동물의학교실)
  • Received : 2022.04.12
  • Accepted : 2022.08.29
  • Published : 2022.08.30
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Abstract

Atopic dermatitis (AD) is a chronic inflammatory skin disease accompanied by severe itching, mainly before five. The aim of this study is to investigate the effects of 405 nm+850 nm LED light therapy on AD-like symptoms in NC/Nga mice. The mice were randomly placed in the normal (Vehicle), atopic dermatitis-induced (CON), and 405 nm + 850 nm LED light therapy (LED) groups. The LED experimental group conducted 405 nm+850 nm wavelength LED ray therapy for 10 minutes a day for seven days. LED light therapy research confirmed the improvement and improvement of Dermatics score and observed the reduction of epidermal tissue thickness caused by dermatitis. Based on the significant decrease of serum IL-1𝛽 and transdermal moisture loss and serum IgE concentration due to LED light therapy, LED light therapy can help restore normal skin conditions in mice that cause atopic dermatitis. This study showed the anti-atopic effect of infrared light and blue light. Light in mice with atopic dermatitis led to the simultaneous use of circular LEDs with two wavelengths.

아토피 피부염(Atopic dermatitis, AD)은 주로 5세 이전에 발병하여 심한 가려움을 동반하는 만성 염증성 피부질환이다. 본 연구의 목적은 NC/Nga 마우스를 AD 유사 증상에 대한 405 nm+ 850 nm LED 광선 치료의 효과를 조사하는 것이다. 마우스는 Normal (Vehicle), 아토피성 피부염 유발군 (CON), 405 nm+ 850 nm LED 광선 치료군 (LED)으로 나누어 난괴법을 이용하여 무작위 배치하여 실험을 진행하였다. LED 실험군은 하루 10분씩 405 nm+ 850 nm 파장의 LED 치료를 7일 간 실시하였다. LED 광선치료 연구는 Dermatics 점수의 개선을 측정하고 피부염으로 인한 표피조직 두께 감소를 관찰하였다. LED 광선 요법으로 인한 혈청 IL-1𝛽의 현저한 감소와 경피 수분 손실 및 혈청 IgE 농도 결과를 바탕으로 LED 광선 치료는 아토피 유발 생쥐의 정상적인 피부 상태 회복에 도움을 주었다. 본 연구 결과는 아토피 피부염 마우스 모델에서 적외선 영역의 광선과 blue light 영역의 광선의 동시 조사치료가 아토피 피부염 치료에 뛰어난 효능을 가지며, 두 파장의 LED의 동시 사용 가능성에 대하여 시사하였다.

Keywords

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