The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
권호 표지
DOI QR코드

DOI QR Code

Reports of 63 Patients Treated with Herbal Medicine to Relieve Symptoms of COVID-19 at One Korean Medicine Clinic: A Retrospective Chart Review

일개 한의의료기관에서 COVID 19 증상 완화를 위해 한약이 투여된 환자 63례에 대한 보고 : 후향적 차트 리뷰 연구

  • Received : 2022.08.25
  • Accepted : 2022.09.30
  • Published : 2022.09.30
Download PDF
⟨ Previous Next ⟩

Abstract

Objectives: The purpose of this study was to report on the cases and prescriptions of non-face-to-face care performed to alleviate COVID-19 symptoms and to present their results. Methods: This study was conducted on 63 COVID-19 patients who visited the Ilsan Hamsoa Korean Medicine Clinic from January 24 to June 11, 2022. We retrospectively analyzed all 63 patient charts and amassed COVID-19-related symptoms and their changes according to clinical characteristics and outcomes. Results: All 63 COVID-19 patients complained of symptoms, such as coughing, sore throat, sputum, fever, headache, myalgia, rhinorrhea, nasal obstruction, postnasal drip, and voice change. In total, 30 patients were administered Eunma-san, 6 patients were administered Eungyo-san plus Mahaenggamseok-tang, 10 patients were administered Galgeunhaegi-tang, 7 patients were administered Eungyo-san, 6 patients were administered Maekmundong-tang, and 4 patients were administered Jugyeopseoggo-tang. Improvements in symptoms due to herbal medicine included the disappearance of COVID-19 fever (22 cases) within 3.59±4.2 days, sore throat (32 cases) within 4.37±2.98 days, and cough (36 cases) within 4.86±3.1 days. Conclusion: Various herbal medicine prescriptions were effective COVID-19 treatments, indicating that herbal medicines may be alternative treatment options for COVID-19. However, the evidence should be supplemented with better designed prospective research on individual prescriptions.

Keywords

References

  1. Ritchie H, Mathieu E, Rodes-Guirao L, Appel C, Giattino C, Ortiz-Ospina E, et al. Coronavirus Pandemic (COVID-19). Our World in Data. Published March 5, 2020. Accessed September 19, 2021. https://ourworldindata.org/covid-vaccinations
  2. Lazarus JV, Ratzan SC, Palayew A, Gostin LO, Larson HJ, Rabin K, et al. A global survey of potential acceptance of a COVID-19 vaccine. Nat Med 2021;27(2):225-8. doi:10.1038/s41591-020-1124-9
  3. Polack FP, Thomas SJ, Kitchin N, Absalon J, Gurtman A, Lockhart S, et al. Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine. N Engl J Med 2020;383(27):2603-15. doi:10.1056/NEJMoa2034577
  4. Kaur RJ, Dutta S, Bhardwaj P, Charan J, Dhingra S, Mitra P, et al. Adverse Events Reported From COVID-19 Vaccine Trials: A Systematic Review. Indian J Clin Biochem. Published online March 27, 2021. doi:10.1007/s12291-021-00968-z
  5. Jorgensen SCJ, Kebriaei R, Dresser LD. Remdesivir: Review of Pharmacology, Pre-clinical Data, and Emerging Clinical Experience for COVID-19. Pharmacother J Hum Pharmacol Drug Ther 2020;40(7):659-71. doi:10.1002/phar.2429doi:10.1002/ phar.2429
  6. Ang L, Song E, Hu XY, Lee HW, Chen Y, Lee MS. Herbal Medicine Intervention for the Treatment of COVID-19: A Living Systematic Review and Cumulative Meta-Analysis. Front Pharmacol 2022;13:906764. doi:10.3389/fphar.2022.906764
  7. Takayama S, Namiki T, Odaguchi H, Arita R, Hisanaga A, Mitani K, et al. Prevention and Recovery of COVID-19 Patients With Kampo Medicine: Review of Case Reports and Ongoing Clinical Trials. Front Pharmacol 2021;12:1484. doi:10.3389/fphar.2021.656246
  8. Jeon SR, Kang JW, Ang L, Lee HW, Lee MS, Kim TH. Complementary and alternative medicine (CAM) interventions for COVID-19: An overview of systematic reviews. Integr Med Res 2022; 11(3):100842. doi:10.1016/j.imr.2022.100842
  9. Kwon SW, Lee WH, Jin C, Jang IS, Jung WS, Moon SK, et al. Could herbal medicine (Soshihotang) be a new treatment option for COVID-19?: a narrative review. Integr Med Res 2020;9(3): 100480. doi:10.1016/j.imr.2020.100480
  10. Kim DS, Chu HM, Min BK, Moon YJ, Park SJ, Kim KH, et al. Telemedicine Center of Korean Medicine for treating patients with COVID-19: a retrospective analysis. Integr Med Res 2020;9(3):100492. doi:10.1016/j.imr.2020.100492
  11. Kim KH, Kang GH, Lee YU, Kang SN, Ji SH, Song JH, et al. Treating COVID-19 with Qingfei Paidu Decoction with and without Ephedra Herba: A Retrospective Case Series. J Intern Korean Med 2022;43(2):264-73. doi:10.22246/jikm.2022.43.2.264
  12. Kang SW, Hong SE, Park JW, Kwon SW, Yoon SH, Kim KI, et al. Safety of Korean Medicine Treatment in Patients Vaccinated with the AstraZeneca COVID-19 Vaccine (ChAdOx1 nCoV-19/AZD1222): A Case Series. J Intern Korean Med 2021;42(4):590-604. doi:10.22246/ jikm.2021.42.4.590
  13. Kim JH, Ko WS, Yoon HJ. Bilateral Facial Palsy in a Patient with Guillain-Barre Syndrome after COVID-19 Vaccination. J Korean Med Ophthalmol Otolaryngol Dermatol 2022;35(1): 81-90. doi:10.6114/JKOOD.2022.35.1.081
  14. Lee S, Park JE, Lee YJ, Kim SH, Lee JY. A Case Report of Taeeumin with Post COVID-19 Syndrome. J Sasang Const Med 2021;33(4): 32-42. doi:10.7730/JSCM.2021.33.4.32
  15. Song JH, Park SY. A Case of Recurrent Herpes Zoster after Coronavirus Disease-2019 (COVID-19) Vaccination. J Korean Med Ophthalmol Otolaryngol Dermatol 2021;34(4): 181-97. doi:10.6114/JKOOD.2021.34.4.181
  16. Kang B, Chu H, Youn BY, Leem J. Prevention and management of adverse events following COVID-19 vaccination using traditional Korean medicine: An online survey of public health doctors. World J Clin Cases 2022;10(28):10053-65. doi:10.12998/wjcc.v10.i28.10053
  17. Micallef MJ, Iwaki K, Ishihara T, Ushio S, Aga M, Kunikata T, et al. The natural plant product tryptanthrin ameliorates dextran sodium sulfate-induced colitis in mice. Int Immunopharmacol 2002 Mar;2(4):565-78. https://doi.org/10.1016/S1567-5769(01)00206-5
  18. Lin H, Wang X, Liu M, Huang M, Shen Z, Feng J, et al. Exploring the treatment of COVID-19 with Yinqiao powder based on network pharmacology. Phytother Res. 2021; 35(5):2651-64. doi:10.1002/ptr.7012
  19. Fan Y, Liu W, Wan R, Du S, Wang A, Xie Q, et al. Efficacy and safety of yinqiao powder combined with western medicine in the treatment of pneumonia: A systematic review and metaanalysis. Complement Ther Clin Pract 2021;42:101297. doi:10.1016/j.ctcp.2020.101297
  20. Hong ND, Jeong GM, Moon JH, Joo SM. Studies on the Efficacy of Combined Preparation of Crude Drugs(XVII)-Effects of 'Bojungikgi-Tang' on the Digestive System, Blood Pressure and Diuretic Actions. Natural Product Sciences 1986; 17(3):223-31.
  21. Lee JG, Koo YS, Lee YG, Park YC. Effect of Mahaenggamseok-tang-gagambang on CD3, CD4, CD8 Cells in OVA-induced Asthmatic Mice. Daejeon University Institute of Oriental Medicine 2008;17(1):67-74.
  22. Hsieh CF, Lo CW, Liu CH, Lin S, Yen HR, Lin TY, et al. Mechanism by which ma-xingshi-gan-tang inhibits the entry of influenza virus. J Ethnopharmacol 2012;143(1):57-67. doi:10.1016/j.jep.2012.05.061
  23. Lin SK, Tsai YT, Lo PC, Lai JN. Traditional Chinese medicine therapy decreases the pneumonia risk in patients with dementia. Medicine (Baltimore) 2016;95(37):e4917. doi:10.1097/MD.0000000000004917
  24. Wang C, Cao B, Liu QQ,, Zou ZQ, Liang ZA. Oseltamivir Compared With the Chinese Traditional Therapy Maxingshigan-Yinqiaosan in the Treatment of H1N1 Influenza. Ann Intern Med 2011;155(4):217-25. doi:10.7326/0003-4819-155-4-201108160-00005
  25. Jeong SH. A study on the anti-inflammatory action of Gagamgalgeunhaegi-tang. [master's thesis]. Daejeon, South Korea, Daejeon University of Korean Medicine 2004.
  26. Woo JS. Effects of Galgun Hegi Tang on Immune Response in Mouse. J Korean Med 1990;11(2):436-57.
  27. Kim HK, Shin SW, Park JH. Inhibitory effect of Galgeunhaeji-Tang on compound 48/80 stimulated allergic reaction. Korean J Oriental & Pathology 2009;23(2):381-8.
  28. Li XM, Srivastava K. Traditional Chinese medicine for the therapy of allergic disorders. Curr Opin Otolaryngol Head Neck Surg 2006; 14(3):191-6. doi:10.1097/01.moo.0000193199.40096.f7
  29. Kamei J, Nakamura R, Ichiki H, Kubo M. Antitussive principles of Glycyrrhizae radix, a main component of the Kampo preparations Bakumondo-to (Mai-men-dong-tang). Eur J Pharmacol 2003;469(1-3):159-63. doi:10.1016/S0014-2999(03)01728-X
  30. Kim H, Jeong HS, Kwon J, Lee KG. Effect of Maekmoondong-tang on the Immunomodulatory action. Korean J Oriental & Pathology 2003;17(4):946-51.
  31. Kim HW, Yang SY, Kim MH, Nam GW, Park YC. Protective Effects of Maekmundong-tang on Elastase-induced Lung Injury. J Korean Orient Med 2011;32(2):63-78.
  32. Jin ZY, Wang HH. Efficacy evaluation of Yinqiaosan and Zhuyegyaotang in adjuvant treatment of patients with severe pneumonia with the same syndrome of Wei and Qi. The clinical Research 2021;4:115-6.
  33. The association of Korean Medicine. Coronavirus Infectious Disease-19 Korean Medicine Treatment Recommendation. Vol 1. 2nd edition. Seoul: The association of Korean Medicine; 2020.
  34. Kim TH. Herbal medicines for fatigue or brain fog in Coronavirus disease 2019 (COVID-19) survivors: a prospective pilot clinical study. [cited 3 July 2022]. Available from: https://cris.nih.go.kr/cris/search/detailSearch.do/20001.