Food Science and Industry (식품과학과 산업)

Korean Society of Food Science and Technology (한국식품과학회)
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A novel approach for dietary regulation of macrophages through mitochondrial energy metabolism

식품을 이용한 대식세포 에너지 대사 조절

  • Yu, Seungmin (Department of Food Science and Biotechnology, Kyung Hee University) ;
  • Kim, Wooki (Department of Food Science and Biotechnology, Kyung Hee University)
  • 유승민 (경희대학교 식품생명공학과) ;
  • 김우기 (경희대학교 식품생명공학과)
  • Received : 2022.09.02
  • Accepted : 2022.09.19
  • Published : 2022.09.30
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Abstract

The regulation of macrophages is a major target for dietary immune modulation for their involvement in both innate and adoptive immune responses. Studies revealed that macrophages are unique in their plasticity to polarize into either inflammatory M1 subset or anti-inflammatory M2 cells. Recently, cellular energy metabolism including both glycolysis and oxidative phosphorylation is demonstrated to control macrophage dichotomy. In this review, the differential utilization of glucose, lipids, amino acids, and irons by M1 and M2 cells are discussed in detail. In addition, several dietary approaches for the alteration of inflammatory M1 cells to M2 phenotypes are reviewed for development of functional foods for immune regulation.

Keywords

References

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