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http://dx.doi.org/10.23093/FSI.2022.55.3.264

A novel approach for dietary regulation of macrophages through mitochondrial energy metabolism  

Yu, Seungmin (Department of Food Science and Biotechnology, Kyung Hee University)
Kim, Wooki (Department of Food Science and Biotechnology, Kyung Hee University)
Publication Information
Food Science and Industry / v.55, no.3, 2022 , pp. 264-275 More about this Journal
Abstract
The regulation of macrophages is a major target for dietary immune modulation for their involvement in both innate and adoptive immune responses. Studies revealed that macrophages are unique in their plasticity to polarize into either inflammatory M1 subset or anti-inflammatory M2 cells. Recently, cellular energy metabolism including both glycolysis and oxidative phosphorylation is demonstrated to control macrophage dichotomy. In this review, the differential utilization of glucose, lipids, amino acids, and irons by M1 and M2 cells are discussed in detail. In addition, several dietary approaches for the alteration of inflammatory M1 cells to M2 phenotypes are reviewed for development of functional foods for immune regulation.
Keywords
diet; immunity; inflammation; macrophage; mitochondria;
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