Restorative Dentistry and Endodontics

The Korean Academy of Conservative Dentistry (대한치과보존학회)
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Effects of calcium silicate cements on neuronal conductivity

  • Derya Deniz-Sungur (Department of Endodontics, Faculty of Dentistry, Hacettepe University) ;
  • Mehmet Ali Onur (Department of Biology, Faculty of Science, Hacettepe University) ;
  • Esin Akbay (Department of Biology, Faculty of Science, Hacettepe University) ;
  • Gamze Tan (Department of Biology, Faculty of Science and Letters, Aksaray University) ;
  • Fugen Dagli-Comert (Department of Endodontics, Faculty of Dentistry, Hacettepe University) ;
  • Taner Cem Sayin (Department of Endodontics, Faculty of Dentistry, Hacettepe University)
  • Received : 2020.11.27
  • Accepted : 2021.05.07
  • Published : 2022.05.31
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Abstract

Objectives: This study evaluated alterations in neuronal conductivity related to calcium silicate cements (CSCs) by investigating compound action potentials (cAPs) in rat sciatic nerves. Materials and Methods: Sciatic nerves were placed in a Tyrode bath and cAPs were recorded before, during, and after the application of test materials for 60-minute control, application, and recovery measurements, respectively. Freshly prepared ProRoot MTA, MTA Angelus, Biodentine, Endosequence RRM-Putty, BioAggregate, and RetroMTA were directly applied onto the nerves. Biopac LabPro version 3.7 was used to record and analyze cAPs. The data were statistically analyzed. Results: None of the CSCs totally blocked cAPs. RetroMTA, Biodentine, and MTA Angelus caused no significant alteration in cAPs (p > 0.05). Significantly lower cAPs were observed in recovery measurements for BioAggregate than in the control condition (p < 0.05). ProRoot MTA significantly but transiently reduced cAPs in the application period compared to the control period (p < 0.05). Endosequence RRM-Putty significantly reduced cAPs. Conclusions: Various CSCs may alter cAPs to some extent, but none of the CSCs irreversibly blocked them. The usage of fast-setting CSCs during apexification or regeneration of immature teeth seems safer than slow-setting CSCs due to their more favorable neuronal effects.

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References

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