The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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A Retrospective Study of the Effectiveness and Safety of Banhasasim-tang, Gumiganghwal-tang, or Pyeongwee-san in Patients with Type 2 Diabetes Mellitus

표준 치료를 받고 있는 제2형 당뇨병 환자에 대한 구미강활탕, 평위산, 반하사심탕 복용이 혈당에 미치는 영향 및 안전성 연구

  • Oh, Seung-hyun (Dept. of Internal Medicine, College of Korean Medicine, Kyung Hee University) ;
  • Lee, Min-seong (Dept. of Internal Medicine, College of Korean Medicine, Kyung Hee University) ;
  • Jung, Woo-nyoung (Dept. of Internal Medicine, College of Korean Medicine, Kyung Hee University) ;
  • Noh, Ji-won (Dept. of Internal Medicine, College of Korean Medicine, Kyung Hee University) ;
  • Ahn, Young-min (Dept. of Internal Medicine, College of Korean Medicine, Kyung Hee University) ;
  • Ahn, Se-young (Dept. of Internal Medicine, College of Korean Medicine, Kyung Hee University) ;
  • Lee, Byung-cheol (Dept. of Internal Medicine, College of Korean Medicine, Kyung Hee University)
  • 오승현 (경희대학교 한의과대학 부속병원 신장내분비내과교실) ;
  • 이민승 (경희대학교 한의과대학 부속병원 신장내분비내과교실) ;
  • 정우녕 (경희대학교 한의과대학 부속병원 신장내분비내과교실) ;
  • 노지원 (경희대학교 한의과대학 부속병원 신장내분비내과교실) ;
  • 안영민 (경희대학교 한의과대학 부속병원 신장내분비내과교실) ;
  • 안세영 (경희대학교 한의과대학 부속병원 신장내분비내과교실) ;
  • 이병철 (경희대학교 한의과대학 부속병원 신장내분비내과교실)
  • Received : 2022.05.19
  • Accepted : 2022.07.04
  • Published : 2022.07.04
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Abstract

Objective: This study was conducted to evaluate the hypoglycemic effect and safety of herbal extracts in patients with type 2 diabetes mellitus. Methods: We investigated 19 hospitalized patients with type 2 diabetes mellitus who were administered Banhasasim-tang (BST), Gumiganghwal-tang (GGT), or Pyeongwee-san (PWS) at Kyung Hee University Korean Medical Hospital for at least three days between January 2012 and December 2021. Their clinical characteristics and laboratory tests were reviewed retrospectively. The glucose-lowering effect of the herbal extracts was assessed by comparing blood glucose levels, including fasting blood sugar (FBS), two-hour postprandial glucose (PP2) levels, and glycated hemoglobin levels. To evaluate the safety of the herbal extract, liver function test and kidney function test results were compared, including aspartate aminotransferase (AST), alanine aminotransferase (ALT), blood urea nitrogen (BUN), and creatinine (Cr). Results: After taking herbal extracts, PP2 and HbA1c levels significantly decreased from 205.82 mg/dL to 171.41 mg/dL and 7.58% to 6.62%, respectively. The safety profile reported no significant difference after taking herbal extracts. Conclusions: BST, GGT, and PWS may have hypoglycemic effects in patients with type 2 diabetes mellitus taking hypoglycemic medication.

Keywords

Acknowledgement

본 연구는 보건복지부의 재원으로 한국보건산업진흥원의 보건의료기술 연구개발사업 지원에 의하여 이루어진 것임(HF20C0022).

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