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http://dx.doi.org/10.22246/jikm.2022.43.3.363

A Retrospective Study of the Effectiveness and Safety of Banhasasim-tang, Gumiganghwal-tang, or Pyeongwee-san in Patients with Type 2 Diabetes Mellitus  

Oh, Seung-hyun (Dept. of Internal Medicine, College of Korean Medicine, Kyung Hee University)
Lee, Min-seong (Dept. of Internal Medicine, College of Korean Medicine, Kyung Hee University)
Jung, Woo-nyoung (Dept. of Internal Medicine, College of Korean Medicine, Kyung Hee University)
Noh, Ji-won (Dept. of Internal Medicine, College of Korean Medicine, Kyung Hee University)
Ahn, Young-min (Dept. of Internal Medicine, College of Korean Medicine, Kyung Hee University)
Ahn, Se-young (Dept. of Internal Medicine, College of Korean Medicine, Kyung Hee University)
Lee, Byung-cheol (Dept. of Internal Medicine, College of Korean Medicine, Kyung Hee University)
Publication Information
The Journal of Internal Korean Medicine / v.43, no.3, 2022 , pp. 363-374 More about this Journal
Abstract
Objective: This study was conducted to evaluate the hypoglycemic effect and safety of herbal extracts in patients with type 2 diabetes mellitus. Methods: We investigated 19 hospitalized patients with type 2 diabetes mellitus who were administered Banhasasim-tang (BST), Gumiganghwal-tang (GGT), or Pyeongwee-san (PWS) at Kyung Hee University Korean Medical Hospital for at least three days between January 2012 and December 2021. Their clinical characteristics and laboratory tests were reviewed retrospectively. The glucose-lowering effect of the herbal extracts was assessed by comparing blood glucose levels, including fasting blood sugar (FBS), two-hour postprandial glucose (PP2) levels, and glycated hemoglobin levels. To evaluate the safety of the herbal extract, liver function test and kidney function test results were compared, including aspartate aminotransferase (AST), alanine aminotransferase (ALT), blood urea nitrogen (BUN), and creatinine (Cr). Results: After taking herbal extracts, PP2 and HbA1c levels significantly decreased from 205.82 mg/dL to 171.41 mg/dL and 7.58% to 6.62%, respectively. The safety profile reported no significant difference after taking herbal extracts. Conclusions: BST, GGT, and PWS may have hypoglycemic effects in patients with type 2 diabetes mellitus taking hypoglycemic medication.
Keywords
type 2 diabetes mellitus; Banhasasim-tang (BST); Gumiganghwal-tang (GGT); Pyeongwee-san (PWS); blood glucose level; Korean medicine;
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Times Cited By KSCI : 5  (Citation Analysis)
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1 Choi HM, Yu BW, Kim MJ, Kim JO. Comparative Study on the Differentiation Effect of Adipogenesis in 3T3-L1 Preadipocyte by 65 Herbal Medicine Prescriptions. J Korean Med Obes Res 2020;20(2):78-87.   DOI
2 Kim JM, Kim SS. Management of hyperglycemia in type 2 diabetes: a summary of new consensus report from the American Diabetes Association and the European Association for the study of diabetes in 2018. J Korean Diabetes 2019;20(1):6-9.   DOI
3 Korean diabetes association. Diabetes fact sheet in Korea 2020. Oct 14 2020. https://www.diabetes.or.kr/pro/news/admin.php?category=A&code=admin&number=1972&mode=view. 6-9,14-16.
4 건강보험심사평가원. 2020 급여의약품 청구현황. 건강보험심사평가원; 2021, p. 76-8.
5 Meng XU. Effects of Banxia Xiexin Decoction on intestinal flora and inflammatory factors of diabetic gastroparesis rats / 中草药. Chinese Traditional and Herbal Drugs 2018;(24):3056-61.
6 Son AH, Koh JY, Lee DK, Shin HS. Review of domestic experimental studies of Korean medicine treatment for diabetes mellitus since 2013. J Int Korean Med 2017;38(1):10-9.   DOI
7 Kim HS. Cardiovascular risk factors in diabetic patients according duration of diabetes mellitus: The sixth Korea national health and nutrition examination survey. JKCA 2018;18(12):208-17.
8 Moon SJ, Baek SM, Park JH, Lee SH, Seo HJ, Kim SG, et al. The use of complementary and alternative medicine in patients with type 2 diabetes mellitus: community based survey. Korean J Orient Int Med 2012;33(3):317-26.
9 Hwang SM, Lee YJ, Kim EJ, Kim HY, Li X, Choi YJ, et al. Effect of Buddleja officinalis in diabetic atherosclerotic mouse model using high fat diet. Kor J Herbology 2009;24(4):55-62.
10 Choi BH, Yoon GM, Kang SB. Effects of hwanggeum -tang aqueous extracts on streptozotocin-induced rat's diabetes and related complications. Korean J Oriental Physiology & Pathology 2011;25(4):683-90.
11 Lee JA, Ha HK, Jung DY, Lee HY, Lee JK, Huang DS, et al. Comparative Study of 25 Herbal Formulas on Anti-Inflammatory Effect. The Journal of Oriental Obstetrics & Gynecology 2010;23(3):101-11.
12 Lee KA. Management of Type 2 Diabetes Mellitus in Adolescents and Young Adult. J Korean Diabetes 2020;21(1):6-10.   DOI
13 Kim YS. Characteristics of Diabetes in Korean Population. J Korean Med Assoc 2008;51(9):799-805.   DOI
14 Diabetes guideline committee. Treatment guideline for diabetes 2021. Seoul: Korean diabetes association; 2021, p. 1-15, 89-139.
15 Lee MS, Jeong SM, Oh SH, Lee HY, Leem HG, Ahn YM, et al. A Retrospective Study on the Effect of the Co-Administration of Ojeok-san and Hypoglycemic Agents on Blood Glucose Levels in Type 2 Diabetes Mellitus. J Int Korean Med 2021;42(1):40-52.
16 Zhang F, Sun X, Qiu G, Zhou X, Liu T, Xiushen H. Study regulation of Banxiaxiexin decoction of fasting blood-glucose and gastrointestinal hormones of diabetic rats. China Press of Traditional Chinese Medicine 2014;30(1):8-10.
17 Jung SY, Jung SE, Kim JH, Ham SH, Yang WM, Kwon BI. Comparative efficacy study of pyeongwi-san(Pingwei-san) of digestive tract disease model in rat. Kor J Herbol 2020;35(2):7-14.
18 Ju DL. Nutritional considerations for diabetic patients on diabetes medication. J Korean Diabetes 2014;15(1):35-40.   DOI
19 Yu CH, Kang SW, Hong SE, Kim KI, Jung HJ, Lee BJ. The effect of herbal medicine on blood glucose in type 2 diabetes patients: A retrospective study. J Int Korean Med 2020;41(6):1066-77.   DOI
20 질병관리청. 국민건강영양조사 만성질환 유병률. https://knhanes.kdca.go.kr/knhanes/sub01/
21 Kim DH, Park SC, Lee JH, Lee HY, Cho MK, Choi JY, et al. Recent research trends in Korean medicine treatment of diabetes mellitusfocusing on domestic articles from 2008 to 2013. Korean J Orient Int Med 2013;34(3):240-55.
22 Kim KJ, Kim GJ. Anti-skin-aging effects of Paeonia Suffruticosa Andrews on maintaining skin collagen in STZ-induced diabetic rats and inhibiting MMP-1 systhesis in human skin fibroblasts. The Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology 2008;21(1):1-15.
23 Oh CH, Shin NS, Kwan J, Lee KG, Lee SR, Lee CH. Antidiabetic effects of water extract from Taraxacum coreanum Nakai in type 2 diabetic mice. Korean J Oriental Physiology & Pathology 2012;26(5):707-13.
24 Roh SS, Choi HJ, Kim DH, Seo YB. Studies of anti-inflammation of Liriopis Tuber to autoimmunune diabetess in NOD mice. Korean J Oriental Physiology & Pathology 2008;22(4):766-70.
25 Choi WS, Yoon KM, Lee YK, Kang SB. Effects of Daeboeum-hwan Aqueous extracts on streptozotocin-induced rat diabetes and related complications. Korean J Orient Int Med 2009;30(4):858-79.
26 Kim EJ, Kim YS. Effects of yanggyuksanhwa-tang on global cerebral ischemia of diabetic rats induced by streptozotocin. Korean J Oriental Physiology & Pathology 2008;22(2):321-7.
27 Jeon SY, Kim WB, Seok EJ, Song SY, Jeong JG, Lee SI. An analysis of clinical studies on banha-sasim-tang. Herbal Formula Science 2018;26(3):267-81.   DOI
28 Kwon OJ, Lee SW, Paik SH, Han SR, Ahn YM, Ahn SY, et al. The effects of Platycodi Radix on obese type 2 diabetes mouse model induced by high fat, high carbohydrate diet. J Korean Oriental Med 2013;34(1):1-14.
29 Lee KJ, Ham IH, Bu YM, Kim HC, Choi HY. Antidiabetic effect of Glechoma longituba (Nakai) Kupr in diabetic rats induced by streptozotocin. Kor J Herbology 2008;23(3):175-80.
30 Cho KW, Zamarron BF, Muir LA, Singer K, Porsche CE, DelProposto JB, et al. Adipose tissue dendritic cells are independent contributors to obesity-induced inflammation and insulin resistance. Journal of Immunology 2016;197(9):3650-61.   DOI