Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Postbiotics Enhance NK Cell Activation in Stress-Induced Mice through Gut Microbiome Regulation

  • Jung, Ye-Jin (Department of R&D Research Center, KookminBio Corporation) ;
  • Kim, Hyun-Seok (Department of R&D Research Center, KookminBio Corporation) ;
  • Jaygal, Gunn (Department of R&D Research Center, KookminBio Corporation) ;
  • Cho, Hye-Rin (Technical Assistance Department (R&D Department), The Food Industrial Promotional Agency of Korea) ;
  • Lee, Kyung bae (Technical Assistance Department (R&D Department), The Food Industrial Promotional Agency of Korea) ;
  • Song, In-bong (Technical Assistance Department (R&D Department), The Food Industrial Promotional Agency of Korea) ;
  • Kim, Jong-Hoon (Department of Bio and Fermentation Convergence Technology, Kookmin University) ;
  • Kwak, Mi-Sun (Department of Bio and Fermentation Convergence Technology, Kookmin University) ;
  • Han, Kyung-Ho (Department of R&D Research Center, KookminBio Corporation) ;
  • Bae, Min-Jung (Technical Assistance Department (R&D Department), The Food Industrial Promotional Agency of Korea) ;
  • Sung, Moon-Hee (Department of R&D Research Center, KookminBio Corporation)
  • Received : 2021.11.14
  • Accepted : 2022.03.07
  • Published : 2022.05.28
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Abstract

Recent studies have revealed that probiotics and their metabolites are present under various conditions; however, the role of probiotic metabolites (i.e., postbiotics in pathological states) is controversial. Natural killer (NK) cells play a key role in innate and adaptive immunity. In this study, we examined NK cell activation influenced by a postbiotics mixture in response to gut microbiome modulation in stress-induced mice. In vivo activation of NK cells increased in the postbiotics mixture treatment group in accordance with Th1/Th2 expression level. Meanwhile, the Red Ginseng treatment group, a reference group, showed very little expression of NK cell activation. Moreover, the postbiotics mixture treatment group in particular changed the gut microbiome composition. Although the exact role of the postbiotics mixture in regulating the immune system of stress-induced mice remains unclear, the postbiotics mixture-induced NK cell activation might have affected gut microbiome modulation.

Keywords

Acknowledgement

This research was supported by the 2020 Collaborative R&BD Program of The Food Industry Promotional Agency of Korea, and a Korea Environmental Industry and Technology Institute (KEITI) grant funded by the Ministry of Environment of Korea.

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