Journal of the Korea Convergence Society (한국융합학회논문지)

Korea Convergence Society (한국융합학회)
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Antibacterial and phagocytosis control of natural extracts on S. mutans

S. mutans에 대한 천연추출물의 항균 및 탐식작용조절

  • 김민영 (호원대학교 치위생학과) ;
  • 황혜정 (건양사이버대학교 보건의료복지학과) ;
  • 강경희 (건양대학교 치위생학과)
  • Received : 2022.04.01
  • Accepted : 2022.05.20
  • Published : 2022.05.28
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Abstract

In this study, the antibacterial and phagocytosis regulation effects of Hordeum vulgare extract and pine needle extract on S. mutans, the causative bacteria of dental caries, were investigated. Ethanol extracts of domestic Hordeum vulgare powder and pine needle powder were used, and the antibacterial and phagocytic ability against S. mutans was confirmed according to the concentration of the extracts. As a result, S. mutans colony formation did not show a significant difference in the Hordeum vulgare extract but was significantly decreased in the pine needle extract. As a result of confirming the phagocytic ability of THP-1 cells for S. mutans, there was no significant difference in the Hordeum vulgare extract, but the phagocytic ability of immune cells was improved in the pine needle extract. Therefore, it suggests that pine needle extract can be used as a material for preventing dental caries.

본 연구에서는 새싹보리 추출물과 솔잎 추출물이 치아우식원인균인 S. mutans에 미치는 항균 및 탐식작용 조절 효과를 알아보고자 하였다. 국내산 새싹보리가루와 솔잎가루의 에탄올 추출물을 이용하며 추출물의 농도에 따른 S. mutans에 대한 항균효과와 탐식작용조절 효과를 확인하였다. 그 결과 S. mutans 집락형성은 새싹보리 추출물에서는 유의적 차이가 나타내지 않았으나, 솔잎 추출물에서는 유의적으로 감소하였다. THP-1 세포의 S. mutans에 대한 탐식작용을 확인한 결과, 새싹보리 추출물에서는 유의적인 차이를 나타내지 않았으나, 솔잎 추출물에서는 면역세포의 탐식작용이 향상되었다. 따라서 솔잎 추출물은 치아우식예방을 위한 소재로 사용될 수 있음을 시사한다.

Keywords

Acknowledgement

This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (Ministry of Education) (NRF-2017R1D1A1B03035544).

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