Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Structure Determination of Heishuixiecaoline A from Valeriana fauriei and Its Content from Different Cultivated Regions by HPLC/PDA Analysis

  • Hyejin, Cho (Department of Plant Science and Technology, Chung-Ang University) ;
  • Ki Hyun, Kim (School of Pharmacy, Sungkyunkwan University) ;
  • Sin Hee, Han (Department of Herbal Crop Research, National Institute of Horticultural and Herbal Science, Rural Development Administration) ;
  • Hak-Jae, Kim (Department of Clinical Pharmacology, College of Medicine, Soonchunhyang University) ;
  • Ik-Hyun, Cho (Department of Convergence Medical Science, College of Korean Medicine, Kyung Hee University) ;
  • Sanghyun, Lee (Department of Plant Science and Technology, Chung-Ang University)
  • Received : 2022.08.19
  • Accepted : 2022.12.02
  • Published : 2022.12.31
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Abstract

A germacrane-type sesquiterpenoid was isolated and purified from a methanol extract of the roots of Valeriana fauriei (RVF) through open column chromatography using silica gel. This compound was verified to be heishuixiecaoline A by spectroscopic analysis. This compound was isolated for the first time from RVF. Quantitative analysis of heishuixiecaoline A from RVF cultivated from three different regions (Eumseong, Jinbu, and Jinan regions) was performed by combining high-performance liquid chromatography with a photodiode array detector. The extract of RVF cultivated in the Jinbu region showed the highest content (9.23 mg/g). In addition, a significant amount of the compound was detected in all RVF samples, which could be expected since it is a characteristic compound of RVF. The sesquiterpenoid group heishuixiecaoline A was isolated from RVF, a resource for various pharmacological substances, and quantitative analysis of RVF cultivated from three different regions was performed. As a result of these experiments, basic data on RVF that can be used in the development and application of pharmaceuticals and health functional foods in the future were obtained.

Keywords

Acknowledgement

This work was performed with the support of Cooperative Research Program for Agriculture Science and Technology Development (PJ01158205), Rural Development Administration, Republic of Korea.

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