Journal of the Korean Applied Science and Technology (한국응용과학기술학회지)

The Korean Society of Applied Science and Technology (한국응용과학기술학회)
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The Protective Effect of Spirulina-derived Phycocyanin on Dermal Fibroblasts Induced by UV Rays

자외선으로 손상을 유도한 피부섬유아세포에서 스피룰리나 유래 피코시아닌의 보호 효과

  • Yang, Jae Chan (Department of Cosmetic & beauty, College of Technology Sciences, Mokwon University)
  • 양재찬 (목원대학교 테크노과학대학 화장품뷰티학과)
  • Received : 2021.10.10
  • Accepted : 2021.10.25
  • Published : 2021.10.30
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Abstract

UV induce oxidative stress and increase matrix metalloproteinase (MMP) expression, resulting in skin aging. Thus, preventing skin damage from ultraviolet B (UVB)-induced skin damage can attenuate skin aging. Spirulina is comprised of prokaryotes a powerful antioxidant. This study aimed to investigate the photoprotective effects of spirulina-derived phycocyanin (PC) against UVB radiation using human skin fibroblast. As a results, PC showed no toxicity at concentrations of 5-40 ㎍/mL in terms of fibroblast viability. Survival rate of UVB-irradiated fibroblast incresased to 73.5% from 50.5% with PC treatment. UVB treatment increased MMP-1 and MMP-9 expression whereas PC treatment decreased it. The results indicate that PC might reduce or prevent skin aging by reducing UVB irradiation-induced skin wrinkles and free radicals.

UV는 산화 스트레스를 유발하고 MMP(Matrix Metalloproteinase) 발현을 증가시켜 피부 노화를 발생시킨다. 따라서 자외선로 인한 피부 손상을 예방하면 피부 노화를 감소시킬 수 있다. 스피룰리나는 강력한 항산화제로 원핵생물로 구성되어 있다. 본 연구는 피부 섬유아세포를 사용하여 UVB 방사선에 대한 스피룰리나 유래 피코시아닌(PC)의 광보호 효과를 조사했다. 그 결과, PC는 섬유아세포 생존율 측면에서 5-40 ㎍/mL 농도에서 독성을 나타내지 않았다. UVB 조사된 섬유아세포의 생존율은 50.5%였으며 PC 처리로 73.5%로 증가했다. MMP-1 및 MMP-9 발현은 UVB 처리로 증가하는 반면 PC 처리한 군에서 감소했다. 이러한 결과를 종합해보면 PC는 UVB 조사로 인한 산화적 손상과 피부노화와 관련된 인자를 감소시켜 노화를 예방할 수 있을 것으로 사료된다.

Keywords

References

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