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http://dx.doi.org/10.12925/jkocs.2021.38.5.1249

The Protective Effect of Spirulina-derived Phycocyanin on Dermal Fibroblasts Induced by UV Rays  

Yang, Jae Chan (Department of Cosmetic & beauty, College of Technology Sciences, Mokwon University)
Publication Information
Journal of the Korean Applied Science and Technology / v.38, no.5, 2021 , pp. 1249-1254 More about this Journal
Abstract
UV induce oxidative stress and increase matrix metalloproteinase (MMP) expression, resulting in skin aging. Thus, preventing skin damage from ultraviolet B (UVB)-induced skin damage can attenuate skin aging. Spirulina is comprised of prokaryotes a powerful antioxidant. This study aimed to investigate the photoprotective effects of spirulina-derived phycocyanin (PC) against UVB radiation using human skin fibroblast. As a results, PC showed no toxicity at concentrations of 5-40 ㎍/mL in terms of fibroblast viability. Survival rate of UVB-irradiated fibroblast incresased to 73.5% from 50.5% with PC treatment. UVB treatment increased MMP-1 and MMP-9 expression whereas PC treatment decreased it. The results indicate that PC might reduce or prevent skin aging by reducing UVB irradiation-induced skin wrinkles and free radicals.
Keywords
Ultraviolet ray; Spirulina; Phycocyanin; Aging; Fibroblast;
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