Anxiety and mood (대한불안의학회지)

Korean Academy of Anxiety Disorders (대한불안의학회)
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Comparison of Mismatch Negativity According to Suicidal Ideation in Patients With Major Depressive Disorder

주요우울장애 환자에서 자살사고 동반 여부에 따른 부적격 짝맞추기 음성파의 비교

  • Lee, Minji (Department of Psychiatry, Soonchunhyang University Seoul Hospital, College of Medicine) ;
  • Lee, Yeon Jung (Department of Psychiatry, Soonchunhyang University Seoul Hospital, College of Medicine) ;
  • Hwang, Jaeuk (Department of Psychiatry, Soonchunhyang University Seoul Hospital, College of Medicine) ;
  • Woo, Sung-il (Department of Psychiatry, Soonchunhyang University Seoul Hospital, College of Medicine) ;
  • Kim, Min Jae (Department of Psychiatry, Soonchunhyang University Seoul Hospital, College of Medicine) ;
  • Kang, Byungjoo (Department of Psychiatry, Soonchunhyang University Seoul Hospital, College of Medicine) ;
  • Kim, Younggeun (Department of Psychiatry, Soonchunhyang University Seoul Hospital, College of Medicine) ;
  • Hahn, Sang-Woo (Department of Psychiatry, Soonchunhyang University Seoul Hospital, College of Medicine)
  • 이민지 (순천향대학교 의과대학 서울병원 정신건강의학교실) ;
  • 이연정 (순천향대학교 의과대학 서울병원 정신건강의학교실) ;
  • 황재욱 (순천향대학교 의과대학 서울병원 정신건강의학교실) ;
  • 우성일 (순천향대학교 의과대학 서울병원 정신건강의학교실) ;
  • 김민재 (순천향대학교 의과대학 서울병원 정신건강의학교실) ;
  • 강병주 (순천향대학교 의과대학 서울병원 정신건강의학교실) ;
  • 김영근 (순천향대학교 의과대학 서울병원 정신건강의학교실) ;
  • 한상우 (순천향대학교 의과대학 서울병원 정신건강의학교실)
  • Received : 2021.05.31
  • Accepted : 2021.08.26
  • Published : 2021.10.30
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Abstract

Objective : Mismatch negativity (MMN) is known to reflect several abnormalities of cognitive functioning. This study is aimed to investigate the differences in MMN among major depressive disorder (MDD) patients with or without suicidal ideation. Methods : Sixty-seven patients with MDD were recruited into this study. MMN was measured by a 64-channel electroencephalography (EEG) using oddball paradigm over the front-central area. Clinical characteristics were assessed using the Beck Anxiety Inventory (BAI), the Beck Depression Inventory-II (BDI-II), and the Beck Scale for Suicide ideation (SSI-BECK). Patients were divided into two groups, no suicidal ideation (N=12) and suicidal ideation (N=55), depending on the presence of suicide ideation in SSI-BECK questionnaires. Results : The MMN latencies were significantly longer in the MDD patients with suicidal ideation than in the MDD patents without suicidal ideation (p<0.05). The MMN amplitudes were not significantly different between the two groups. Conclusion : Suicidal ideation may be associated with longer MMN latencies, and it suggests that MMN may play a potential role in assessing the suicidal risk among MDD patients.

Keywords

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