DOI QR코드

DOI QR Code

Usefulness of cyclic thermal therapy and red blood cell scintigraphy in patients with chemotherapy-induced peripheral neuropathy

  • Kim, Minjoo (Department of Nuclear Medicine, Molecular Imaging & Therapeutic Medicine Research Center, Research Institute of Clinical Medicine, Biomedical Research Institute, Jeonbuk National University Medical School and Hospital) ;
  • Kim, Eun-Mi (Department of Nuclear Medicine, Molecular Imaging & Therapeutic Medicine Research Center, Research Institute of Clinical Medicine, Biomedical Research Institute, Jeonbuk National University Medical School and Hospital) ;
  • Oh, Phil-Sun (Department of Nuclear Medicine, Molecular Imaging & Therapeutic Medicine Research Center, Research Institute of Clinical Medicine, Biomedical Research Institute, Jeonbuk National University Medical School and Hospital) ;
  • Lim, Seok Tae (Department of Nuclear Medicine, Molecular Imaging & Therapeutic Medicine Research Center, Research Institute of Clinical Medicine, Biomedical Research Institute, Jeonbuk National University Medical School and Hospital) ;
  • Sohn, Myung-Hee (Department of Nuclear Medicine, Molecular Imaging & Therapeutic Medicine Research Center, Research Institute of Clinical Medicine, Biomedical Research Institute, Jeonbuk National University Medical School and Hospital) ;
  • Song, Eun-Kee (Division of Medical Oncology & Hematology, Department of Internal Medicine, Jeonbuk National University Medical School and Hospital) ;
  • Park, Keon Uk (Department of Hematology/Oncology, Keimyung University Dongsan Hospital) ;
  • Kim, Jin Young (Department of Hematology/Oncology, Keimyung University Dongsan Hospital) ;
  • Won, Kyoung Sook (Department of Nuclear Medicine, Keimyung University Dongsan Hospital) ;
  • Jeong, Hwan-Jeong (Department of Nuclear Medicine, Molecular Imaging & Therapeutic Medicine Research Center, Research Institute of Clinical Medicine, Biomedical Research Institute, Jeonbuk National University Medical School and Hospital)
  • Received : 2021.03.05
  • Accepted : 2021.06.07
  • Published : 2021.10.01

Abstract

Background: Pharmacological and non-pharmacological therapies have been used to treat patients with chemotherapy-induced peripheral neuropathy (CIPN). However, the effect of therapies in cancer patients has yet to be investigated comprehensively. We hypothesized that cyclic thermal therapy would improve blood flow and microcirculation and improve the symptoms driven by CIPN. Methods: The criteria of assessment were blood volume in region of interest (ROI) in the images, and European Organization for Research and Treatment of Cancer-Quality of Life Questionnaire-Chemotherapy-Induced Peripheral Neuropathy 20 questionnaire scores. The blood volume was quantified by using red blood cell (RBC) scintigraphy. All patients were treated 10 times during 10 days. The thermal stimulations, between 15° and 41°, were repeatedly delivered to the patient's hands. Results: The total score of the questionnaires, the score of questions related to the upper limbs, the score of questions closely related to the upper limbs, and the score excluding the upper limbs questions was decreased. The blood volume was decreased, and the variance of blood volume was decreased. During cooling stimulation, the blood volume was decreased, and its variance was decreased. During warming stimulation, the blood volume was decreased, and its variance was decreased. Conclusions: We suggest that cyclic thermal therapy is useful to alleviate CIPN symptoms by blood circulation improvement. RBC scintigraphy can provide the quantitative information on blood volume under certain conditions such as stress, as well as rest, in peripheral tissue.

Keywords

Acknowledgement

This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HI15C1529) and the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (2020R1F1A1050711).

References

  1. Windebank AJ, Grisold W. Chemotherapy-induced neuropathy. J Peripher Nerv Syst 2008; 13: 27-46. https://doi.org/10.1111/j.1529-8027.2008.00156.x
  2. Armstrong T, Almadrones L, Gilbert MR. Chemotherapyinduced peripheral neuropathy. Oncol Nurs Forum 2005; 32: 305-11. https://doi.org/10.1188/05.ONF.305-311
  3. Kumar SP, Sisodia V. Chemotherapy-induced or chemotherapy-associated? Does physical therapy play a role in prevention and/or management of peripheral neurotoxicity and neuropathy? Indian J Palliat Care 2013; 19: 77-8. https://doi.org/10.4103/0973-1075.110245
  4. Wolf S, Barton D, Kottschade L, Grothey A, Loprinzi C. Chemotherapy-induced peripheral neuropathy: prevention and treatment strategies. Eur J Cancer 2008; 44: 1507-15. https://doi.org/10.1016/j.ejca.2008.04.018
  5. Woo IS. Recent updates on chemotherapy-induced peripheral neuropathy. Korean J Med 2015; 88: 35-7. https://doi.org/10.3904/kjm.2015.88.1.35
  6. Barton DL, Wos EJ, Qin R, Mattar BI, Green NB, Lanier KS, et al. A double-blind, placebo-controlled trial of a topical treatment for chemotherapy-induced peripheral neuropathy: NCCTG trial N06CA. Support Care Cancer 2011; 19: 833-41. https://doi.org/10.1007/s00520-010-0911-0
  7. Wickham R. Chemotherapy-induced peripheral neuropathy: a review and implications for oncology nursing practice. Clin J Oncol Nurs 2007; 11: 361-76. https://doi.org/10.1188/07.CJON.361-376
  8. Sutterfield SL, Caldwell JT, Post HK, Lovoy GM, Banister HR, Ade CJ. Lower cutaneous microvascular reactivity in adult cancer patients receiving chemotherapy. J Appl Physiol (1985) 2018; 125: 1141-9. https://doi.org/10.1152/japplphysiol.00394.2018
  9. Akasaki Y, Miyata M, Eto H, Shirasawa T, Hamada N, Ikeda Y, et al. Repeated thermal therapy up-regulates endothelial nitric oxide synthase and augments angiogenesis in a mouse model of hindlimb ischemia. Circ J 2006; 70: 463-70. https://doi.org/10.1253/circj.70.463
  10. Tepperman PS, Devlin M. The therapeutic use of local heat and cold. Can Fam Physician 1986; 32: 1110-4.
  11. Johnson JM, Minson CT, Kellogg DL Jr. Cutaneous vasodilator and vasoconstrictor mechanisms in temperature regulation. Compr Physiol 2014; 4: 33-89.
  12. Maeda H, Kurose T, Nosaka S, Kawamata S. Microvascular circulation at cool, normal and warm temperatures in rat leg muscles examined by histochemistry using Lycopersicon esculentum lectin. Acta Histochem 2014; 116: 1096-103. https://doi.org/10.1016/j.acthis.2014.05.006
  13. Salmi AM, Hong C, Futrell JW. Preoperative cooling and warming of the donor site increase survival of skin flaps by the mechanism of ischaemic preconditioning: an experimental study in rats. Scand J Plast Reconstr Surg Hand Surg 1999; 33: 163-7. https://doi.org/10.1080/02844319950159406
  14. Roque FR, Hernanz R, Salaices M, Briones AM. Exercise training and cardiometabolic diseases: focus on the vascular system. Curr Hypertens Rep 2013; 15: 204-14. https://doi.org/10.1007/s11906-013-0336-5
  15. Bang SH, Oh YS, Park HJ, Lee TK, Yang JS, Lee SM, et al. Evaluation of finger blood flow with Tc-99m MDP (methylene diphosphonate). Korean J Intern Med 1992; 7: 94-101. https://doi.org/10.3904/kjim.1992.7.2.94
  16. Kunnen JJ, Dahler HP, Doorenspleet JG, van Oene JC. Effects of intra-arterial ketanserin in Raynaud's phenomenon assessed by 99MTc-pertechnetate scintigraphy. Eur J Clin Pharmacol 1988; 34: 267-71. https://doi.org/10.1007/BF00540954
  17. Sarikaya A, Ege T, Firat MF, Duran E. Assessment of digital ischaemia and evaluation of response to therapy by 99mTc sestamibi limb scintigraphy after local cooling of the hands in patients with vasospastic Raynaud's syndrome. Nucl Med Commun 2004; 25: 207-11. https://doi.org/10.1097/00006231-200402000-00019
  18. Kaminaga T, Takada K, Kutomi K, Imai E, Furui S. Improvement in cold-induced Raynaud's syndrome with administration of ticlopidine hydrochloride detected by Tc-99m DTPA human serum albumin scintigraphy. Clin Nucl Med 2002; 27: 131-2. https://doi.org/10.1097/00003072-200202000-00013
  19. Garai I, Csiki Z, Galuska L. Is MIBI the best choice for the evaluation of hand perfusion during cold test provocation? Nucl Med Commun 2005; 26: 269-70. https://doi.org/10.1097/00006231-200503000-00012
  20. Habash RW, Bansal R, Krewski D, Alhafid HT. Thermal therapy, part 1: an introduction to thermal therapy. Crit Rev Biomed Eng 2006; 34: 459-89. https://doi.org/10.1615/CritRevBiomedEng.v34.i6.20
  21. Postma TJ, Aaronson NK, Heimans JJ, Muller MJ, Hildebrand JG, Delattre JY, et al. The development of an EORTC quality of life questionnaire to assess chemotherapy-induced peripheral neuropathy: the QLQ-CIPN20. Eur J Cancer 2005; 41: 1135-9. https://doi.org/10.1016/j.ejca.2005.02.012
  22. Wolf SL, Barton DL, Qin R, Wos EJ, Sloan JA, Liu H, et al. The relationship between numbness, tingling, and shooting/burning pain in patients with chemotherapy-induced peripheral neuropathy (CIPN) as measured by the EORTC QLQ-CIPN20 instrument, N06CA. Support Care Cancer 2012; 20: 625-32. https://doi.org/10.1007/s00520-011-1141-9
  23. Hing WA, White SG, Bouaaphone A, Lee P. Contrast therapy--a systematic review. Phys Ther Sport 2008; 9: 148-61. https://doi.org/10.1016/j.ptsp.2008.06.001
  24. Mols F, van de Poll-Franse LV, Vreugdenhil G, Beijers AJ, Kieffer JM, Aaronson NK, et al. Reference data of the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-CIPN20 Questionnaire in the general Dutch population. Eur J Cancer 2016; 69: 28-38. https://doi.org/10.1016/j.ejca.2016.09.020
  25. Piao CH, Fan YJ, Nguyen TV, Song CH, Jeong HJ, Chai OH. Effects of thermal therapy combined with blue light-emitting diode irradiation on trimellitic anhydride-induced acute contact hypersensitivity mouse model. J Dermatolog Treat 2020. doi: 10.1080/09546634.2020.1809622.
  26. Diskin CJ, Stokes TJ, Dansby LM, Carter TB, Radcliff L, Thomas SG. Towards an understanding of oedema. BMJ 1999; 318: 1610-3. https://doi.org/10.1136/bmj.318.7198.1610
  27. Wang SJ, Lee CH, Kang HG, Kim KW, Kim M, Jeong HJ, et al. Peripheral vasoreactivity in acute ischemic stroke with hemiplegia. Sci Rep 2021; 11: 8531. https://doi.org/10.1038/s41598-021-88050-9